Chemokine receptor CCR5 in interferon-treated multiple sclerosis
| Autor: | Jesper Eugen-Olsen, Jette L. Frederiksen, P. Wittenhagen, Thomas Birk Kristiansen, Torben Lykke Sørensen, Finn Sellebjerg, Peter Garred |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Central Nervous System Genetic Markers Male Chemokine Genotype Receptors CCR5 Chemokine receptor CCR5 viruses DNA Mutational Analysis Monocytes Pathogenesis Chemokine receptor Multiple Sclerosis Relapsing-Remitting Gene Frequency medicine Humans Genetic Predisposition to Disease Genetic Testing Promoter Regions Genetic Allele frequency Polymorphism Genetic biology Multiple sclerosis Monocyte virus diseases Interferon-beta General Medicine Middle Aged medicine.disease medicine.anatomical_structure Neurology Mutation Immunology biology.protein Female Interferons Neurology (clinical) CC chemokine receptors Biomarkers |
| Zdroj: | Acta Neurologica Scandinavica. 115:413-418 |
| ISSN: | 1600-0404 0001-6314 |
| DOI: | 10.1111/j.1600-0404.2007.00826.x |
| Popis: | Objective – To study the relationship between CC chemokine receptor CCR5 expression and disease activity in multiple sclerosis (MS) patients treated with β-interferon (IFN-β). Methods – The CCR5 Δ32 allele and a CCR5 promoter polymorphism associated with cell surface expression of CCR5 were analyzed in 109 patients with relapsing–remitting MS treated with IFN-β who were followed clinically for 1 year. Cellular CCR5 expression was measured by flow cytometry. Results – Patients with MS had a higher percentage of CCR5-positive monocytes than healthy controls. Increased monocyte expression of CCR5 correlated weakly with an increased short-term relapse risk but there was no relationship between CCR5 Δ32 allele and CCR5 promoter polymorphism genotypes and relapse risk. Conclusions – The results do not support a major role of CCR5 in the pathogenesis of relapses in MS patients treated with IFN-β, but it is possible that monocyte CCR5 expression may be used as a marker of disease activity. |
| Databáze: | OpenAIRE |
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