Severe Non-Islet Cell Hypoglycemia From Ileum-Origin Gastrointestinal Stromal Tumor Producing Insulin-Like Growth Factor-2 in a Patient With Liver Cirrhosis Due to Chronic Hepatitis B
| Autor: | Yuko Ono, Sho Furukawa, Koshi Hashimoto, Takenori Okumura, Takafumi Tsuchiya, Kohzo Takebayashi, Kenji Hara, Hiroyuki Shinozaki, Mio Kubo, Toshihiko Inukai, Mototaka Yamauchi, Atsushi Ujiie |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Cirrhosis medicine.medical_treatment Case Report 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Hypoglycemia Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Stromal tumor geography geography.geographical_feature_category GiST biology business.industry Steroid therapy Insulin NICTH General Medicine medicine.disease Islet Insulin-like growth factor 2 Liver cirrhosis Prednisolone biology.protein business GIST medicine.drug |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr4326 |
| Popis: | Non-islet cell tumor hypoglycemia (NICTH) is a rare paraneoplastic syndrome, and NICTH associated with gastrointestinal stromal tumor (GIST) is even more rare. Herein, we describe a patient with severe NICTH due to GIST who had developed liver cirrhosis as a consequence of chronic hepatitis B. Although circulating insulin, C-peptide, and insulin-like growth factor-1 (IGF-1) levels were significantly decreased, in contrast to our expectations, the growth hormone (GH) level was slightly elevated. Steroid therapy with prednisolone appeared to be effective for the prevention of severe and continuous hypoglycemia. |
| Databáze: | OpenAIRE |
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