Reactive oxygen species and synthetic antioxidants as angiogenesis modulators: Clinical implications
| Autor: | Piotr Skopiński, Agata Białoszewska, Agata Hevelke, Ewa Skopińska-Różewska, Barbara J. Bałan, Jarosław Jóźwiak, Dorota M. Radomska-Leśniewska, Dariusz Rokicki |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Antioxidant Free Radicals Angiogenesis medicine.medical_treatment Pharmacology Biology medicine.disease_cause Angiogenesis Modulating Agents Antioxidants Neovascularization 03 medical and health sciences chemistry.chemical_compound medicine Animals Humans PI3K/AKT/mTOR pathway chemistry.chemical_classification Reactive oxygen species Neovascularization Pathologic General Medicine Oxidative Stress 030104 developmental biology chemistry Biochemistry Curcumin medicine.symptom Reactive Oxygen Species Oxidative stress Signal Transduction |
| Zdroj: | Pharmacological Reports. 68:462-471 |
| ISSN: | 1734-1140 |
| DOI: | 10.1016/j.pharep.2015.10.002 |
| Popis: | Angiogenesis is important for normal functioning of organism and its disturbances are observed in many diseases, called angiogenesis-related states. Reactive oxygen species (ROSs) play an important role in physiology, but high level of cellular ROSs is cytotoxic and mutagenic for the cells, i.e. it can lead to oxidative stress. In this review we discuss close relationship between ROSs and angiogenesis process. Substances counteracting free radicals or their action and oxidative stress are known as antioxidants. We postulate that antioxidants, by affecting angiogenesis, may modulate therapy results in the case of angiogenesis-related disease. Herein, we present some antioxidant preparations of synthetic (N-acetylcysteine, curcumin and its analogs, Probucol, oleane tripertenoid, EGCG synthetic analogs) and nature-identical (vitamin E and C) origin. Then, we analyze their angiogenic properties and their multidirectional molecular effect on angiogenesis. Most preparations reduce neovascularization and diminish the level of proangiogenic molecules, downregulating signaling pathways related to angiogenesis. Moreover, we discuss studies concerning anticancer properties of presented synthetic antioxidants and their application in several angiogenesis-related diseases. We conclude that therapy in angiogenesis-related diseases should be planned with consideration of the angiogenic status of the patient. |
| Databáze: | OpenAIRE |
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