Vagus nerve electroneurogram-based detection of acute pentylenetetrazol induced seizures in rats
| Autor: | Lars Stumpp, Antoine Nonclercq, Joaquin Cury, Riem El Tahry, Pascal Doguet, Simone Vespa, Jean Delbeke, Hugo Smets |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vagus Nerve Stimulation
Computer Networks and Communications medicine.medical_treatment Biophysics seizure detection Stimulation Neurosciences. Biological psychiatry. Neuropsychiatry responsive VNS VENG 03 medical and health sciences 0302 clinical medicine Seizures Electroneurogram Medicine Animals Pentylenetetrazol 030304 developmental biology 0303 health sciences Epilepsy Téléinformatique interconnexion ordinateurs business.industry General Neuroscience Vagus Nerve General Medicine Vagus nerve Peripheral Rats Treatment Outcome Seizure detection Anesthesia pentylenetetrazol (PTZ) Refractory epilepsy Pentylenetetrazole Neurology (clinical) business 030217 neurology & neurosurgery Vagus nerve stimulation medicine.drug RC321-571 |
| Zdroj: | International journal of neural systems Brain Stimulation, Vol 14, Iss 6, Pp 1725-1726 (2021) |
| Popis: | On-demand stimulation improves the efficacy of vagus nerve stimulation (VNS) in refractory epilepsy. The vagus nerve is the main peripheral parasympathetic connection and seizures are known to exhibit autonomic symptoms. Therefore, we hypothesized that seizure detection is possible through vagus nerve electroneurogram (VENG) recording. We developed a metric able to measure abrupt changes in amplitude and frequency of spontaneous vagus nerve action potentials. A classifier was trained using a "leave-one-out"method on a set of 6 seizures and 3 control recordings to utilize the VENG spike feature-based metric for seizure detection. We were able to detect pentylenetetrazol (PTZ) induced acute seizures in 6/6 animals during different stages of the seizure with no false detection. The classifier detected the seizure during an early stage in 3/6 animals and at the onset of tonic clonic stage of the seizure in 3/6 animals. EMG and motion artefacts often accompany epileptic activity. We showed the "epileptic"neural signal to be independent from EMG and motion artefacts. We confirmed the existence of seizure related signals in the VENG recording and proved their applicability for seizure detection. This detection might be a promising tool to improve efficacy of VNS treatment by developing new responsive stimulation systems. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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