Alterations in Plasma Oxidative Stress Markers After Laparoscopic Operations of the Upper and Lower Abdomen
| Autor: | Alexandros D. Tselepis, Glantzounis G, I. Tsimaris, Evangelos C. Tsimoyiannis, C. Thomas, Dimitrios Galaris |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Colectomies medicine.medical_specialty Posture Urology Fundoplication Hernia Inguinal Vagotomy Thiobarbituric Acid Reactive Substances Transaminase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pneumoperitoneum medicine TBARS Humans Aspartate Aminotransferases Prospective Studies Colectomy Aged biology business.industry Alanine Transaminase Middle Aged medicine.disease Uric Acid Oxidative Stress medicine.anatomical_structure chemistry Alanine transaminase 030220 oncology & carcinogenesis Anesthesia biology.protein Uric acid Abdomen Female Laparoscopy 030211 gastroenterology & hepatology Lipid Peroxidation Cardiology and Cardiovascular Medicine business Pneumoperitoneum Artificial |
| Zdroj: | Angiology. 56:459-465 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331970505600414 |
| Popis: | The patient’s position during laparoscopic surgery can have a clinically relevant effect on lower limb and splanchnic circulation; this factor has not yet been investigated with respect to oxidative stress markers. In order to assess this effect, a prospective clinical trial was designed wherein 2 groups of patients were studied. In group A, 15 patients underwent upper abdominal nonhepatobiliary operations (13 modified Nissen fundoplications and 2 Taylor vagotomies) in the head-up position. In group B, 15 patients underwent lower abdominal operations (10 laparoscopic colectomies and 5 inguinal hernia repairs) in the head-down position. The pneumoperitoneum was maintained at 14 mm Hg in all cases. Plasma concentrations of thiobarbituric-acid reactive substances (TBARS), a marker of lipid peroxidation, plasma total antioxidant status (TAS), and serum uric acid concentrations were measured preoperatively, 5 minutes after deflation of the pneumoperitoneum, and 24 hours postoperatively. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) serum activities were measured preoperatively and 24 hours postoperatively. In group A, there was a significant increase in TBARS levels (p |
| Databáze: | OpenAIRE |
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