Retinol binding protein as early marker of fetal growth restriction in first trimester maternal serum

Autor:	Ambrogio P. Londero, Anna Biasioli, Serena Bertozzi, Lorenza Driul, Maria Ceraudo, Giuliana Stel, Arrigo Fruscalzo, Diego Marchesoni, Francesco Curcio
Rok vydání:	2013
Předmět:	Adult medicine.medical_specialty INSULIN-RESISTANCE PREECLAMPSIA Endocrinology Diabetes and Metabolism Adipokine Gestational Age Biology Preeclampsia chemistry.chemical_compound Endocrinology Insulin resistance Pre-Eclampsia Pregnancy Internal medicine medicine Humans Retrospective Studies Fetal Growth Retardation Retinol Obstetrics and Gynecology Gestational age medicine.disease Pregnancy Trimester First Retinol binding protein Transthyretin chemistry Case-Control Studies biology.protein Gestation Female Retinol-Binding Proteins Plasma Biomarkers Maternal Age
Zdroj:	Gynecological Endocrinology. 29:323-326
ISSN:	1473-0766 0951-3590
DOI:	10.3109/09513590.2012.743013
Popis:	Serum retinol binding protein (RBP4) is the binding protein for retinol, being delivered into the circulation through the carrier protein transthyretin (TTR) together with thyroxin (T4). RBP4 has also been recently indicated as a new adipokine implicated in insulin resistance and metabolism regulation.To investigate the role of RBP4 as early markers of fetal growth restriction (FGR) and preeclampsia (PE) in maternal serum during the first trimester of pregnancy.Retrospective case control study in patients between the 12th and the 14th week of gestation. RBP4, TTR and T4 concentration was assessed in maternal serum of three groups of women: 15 and 14 patients later developing respectively FGR and PE were compared with 11 patients having a normal pregnancy.All women were Caucasian and the mean maternal age was 33.62 years (±5.50). RBP4 resulted lower in the FGR than in the control group (11.00 versus 16.00 µg/ml, p0.05) and than in the PE group (15.00 µg/ml, p = 0.075), both in bivariate and multivariate analysis. No difference was observed in TTR and T4 concentration.RBP4 seems to play a role as early marker of FGR but not PE in first trimester maternal serum.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b26fcb5827fdd620cc464647d430437 https://doi.org/10.3109/09513590.2012.743013 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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