Detection of varicella-zoster virus DNA in peripheral mononuclear cells from patients with Ramsay Hunt syndrome or zoster sine herpete
| Autor: | Yozo Orita, Kihei Terada, Takahiro Niizuma, Shoji Kawano, Naoki Kataoka, Takeshi Akisada |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Herpesvirus 3 Human Adolescent viruses Facial Paralysis Antibodies Viral medicine.disease_cause Herpes Zoster Herpes Zoster Oticus Polymerase Chain Reaction Virus Herpesviridae Virology Bell's palsy medicine Humans Cranial nerve disease Aged integumentary system Ramsay Hunt syndrome business.industry Varicella zoster virus Antibody titer Infant virus diseases Middle Aged biochemical phenomena metabolism and nutrition medicine.disease Facial paralysis stomatognathic diseases Infectious Diseases Immunoglobulin M Child Preschool Immunoglobulin G DNA Viral Leukocytes Mononuclear medicine.symptom business |
| Zdroj: | Journal of Medical Virology. 56:359-363 |
| ISSN: | 1096-9071 0146-6615 |
| Popis: | On the basis of alterations in varicella-zoster virus (VZV) antibody titers, it appears that Bell's palsy in some patients could be associated with VZV reactivation, that is, zoster sine herpete. To obtain stronger evidence of this association, polymerase chain reaction (PCR) was used to detect VZV DNA in auricular lesions or peripheral blood mononuclear cells (PBMCs) from Bell's palsy or Ramsay Hunt syndrome patients. VZV DNA was detected in the auricular lesions of Ramsay Hunt syndrome, in PBMCs from 2 Ramsay Hunt syndrome patients, and in 4 of 17 samples from 16 Bell's palsy patients. Three of these four positive patients were thought to have zoster sine herpete because of hearing difficulty, vertigo, and pain. VZV IgM antibodies were positive in 1 of the 2 patients with Ramsay Hunt syndrome, and in 2 of the 17 samples from the Bell's palsy patients. VZV IgG antibody titers during the acute phase were significantly higher in the patients positive for the PCR or VZV IgM antibody than in those negative for them. These findings provide evidence that Bell's palsy in some patients could be associated with VZV reactivation. |
| Databáze: | OpenAIRE |
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