Autophagy in Tumorigenesis and Cancer Treatment
| Autor: | Guan-Qing Zhang, Xiaoyin Xu, Dong-Wei Xu, Zong-Wei Wang, Tong-Xiang Liu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Programmed cell death Epidemiology Autophagy Public Health Environmental and Occupational Health Cancer Mitochondrion Biology medicine.disease_cause medicine.disease Malignant transformation Cell biology Cell Transformation Neoplastic Oncology Cytoplasm Neoplasms medicine Animals Anticarcinogenic Agents Humans Signal transduction Carcinogenesis |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 16:2167-2175 |
| ISSN: | 1513-7368 |
| Popis: | Autophagy is a self-digestion process, wrapping cytoplasmic proteins or organelles to form vesicles for degradation in lysosomes. The process plays an important role in the maintenance of intracellular homostasis. Here we overview articles on autophagy and cancer/tumors in Pubmed and found 327 articles. Autophagy exists in many tumors and is involved in cell malignant transformation and tumor cell growth. In early phases of tumorigenesis, autophagy clears the abnormally folded proteins and dysfunctional organelles such as mitochondria. Autophagy can also inhibit cell stress responses and prevent genetic damage. When a tumor develops, autophagy helps tumor cells survive nutritional deficiencies and hypoxic conditions. Studies of autophagy in the occurrence and progression of tumors should provide new therapeutic strategies for tumors. |
| Databáze: | OpenAIRE |
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