Liver Microphysiological Systems for Predicting and Evaluating Drug Effects
| Autor: | Xinning Yang, Vikram Patel, Rajnikanth Madabushi, Alexandre J.S. Ribeiro, David G. Strauss |
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| Rok vydání: | 2019 |
| Předmět: |
Pharmacology
Drug business.industry media_common.quotation_subject Drug Evaluation Preclinical Reviews Computational biology Review Microfluidic Analytical Techniques 030226 pharmacology & pharmacy Models Biological Hepatic function 03 medical and health sciences 0302 clinical medicine Liver metabolism Drug development Liver 030220 oncology & carcinogenesis Lab-On-A-Chip Devices Medicine Humans Pharmacology (medical) business Drug metabolism media_common |
| Zdroj: | Clinical Pharmacology and Therapeutics |
| ISSN: | 1532-6535 |
| Popis: | Liver plays a major role in drug metabolism and is one of the main sites of drug adverse effects. Microphysiological systems (MPS), also known as organs-on-a-chip, are a class of microfluidic platforms that recreate properties of tissue microenvironments. Among different properties, the liver microenvironment is three-dimensional, fluid flows around its cells, and different cell types regulate its function. Liver MPS aim to recreate these properties and enable drug testing and measurement of functional endpoints. Tests with these systems have demonstrated their potential for predicting clinical drug effects. Properties of liver MPS that improve the physiology of cell culture are reviewed, specifically focusing on the importance of recreating a physiological microenvironment to evaluate and model drug effects. Advances in modeling hepatic function by leveraging MPS are addressed, noting the need for standardization in the use, quality control, and interpretation of data from these systems. |
| Databáze: | OpenAIRE |
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