Neuropsychiatric Lupus with Antibody-Mediated Striatal Encephalitis
| Autor: | Suresh C. Patel, Brendan P Kelley, Brent Griffith, John Corrigan |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_treatment Central nervous system Cross Reactions Receptors N-Methyl-D-Aspartate Young Adult 03 medical and health sciences 0302 clinical medicine immune system diseases medicine Humans Radiology Nuclear Medicine and imaging Lupus vasculitis skin and connective tissue diseases Aged Autoantibodies Autoimmune disease Autoimmune encephalitis Systemic lupus erythematosus business.industry Adult Brain Lupus Vasculitis Central Nervous System Autoantibody Plasmapheresis medicine.disease Corpus Striatum 030104 developmental biology medicine.anatomical_structure Antibodies Antinuclear Immunology Encephalitis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a5842 |
| Popis: | Systemic lupus erythematosus is a chronic autoimmune disease characterized by the production of autoantibodies resulting in tissue injury across multiple organs; up to 50% of patients develop neurologic involvement, collectively referred to as neuropsychiatric systemic lupus erythematosus. The cases in this clinical report will highlight a subtype of neuropsychiatric systemic lupus erythematosus demonstrating imaging findings of striatal inflammation responsive to plasmapheresis similar to those in the subset of N-methyl-D-aspartate receptor autoimmune encephalitis that involves the striatum. Although the cause for this striking imaging appearance is not definitely known, literature will be presented supporting the hypothesis that it is due to peripheral anti-double-stranded DNA antibodies entering the central nervous system to cross-react with N-methyl-D-aspartate receptor antigens. |
| Databáze: | OpenAIRE |
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