Effect of a high dose of fluoride on resorbing osteoclasts in vivo
| Autor: | Myra E. Flores, Lars Hammarström, Sven Lindskog, Eva Lilja |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Dose-Response Relationship Drug Osteoclasts Rats Inbred Strains Resorption Rats chemistry.chemical_compound Endocrinology chemistry Rat molar In vivo Single high dose Internal medicine Sodium fluoride medicine Systemic administration Animals Sodium Fluoride Gradual increase Bone Resorption General Dentistry Fluoride |
| Zdroj: | Scandinavian journal of dental research. 97(6) |
| ISSN: | 0029-845X |
| Popis: | — Histomorphometric analysis of osteoclasts resorbing bone above the erupting first rat molar tooth germ was made at 1, 2, 6, 24, and 48 h following systemic administration of a single high dose of sodium fluoride. Compared to the number of osteoclasts in control rats, a significant reduction was observed in the number of actively resorbing osteoclasts in fluoride-injected rats at 2 and 6 h after dose administration, after which a gradual increase to control levels was observed. A locally increased number of inactive osteoclasts, not attached to bone surfaces, accompanied the reduced number of active osteoclasts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text