Concise Synthesis of 1H-Pyrazin-2-ones and 2-Aminopyrazines

Autor:	David Orain, Peter Meier, Isabelle Adam
Rok vydání:	2004
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Primary (chemistry) Pyrazine Nucleophilic aromatic substitution Chemistry Organic Chemistry Organic chemistry General Medicine Combinatorial chemistry High yielding Amino acid
Zdroj:	Synlett. 2004:2031-2033
ISSN:	1437-2096 0936-5214
Popis:	Convenient syntheses of lH-pyrazin-2-ones and 2-aminopyrazines are described. By coupling Boc-protected amino acids with α-amino ketones or with amino alcohols and subsequent oxidation, 1H-pyrazin-2-ones were obtained. Transformation into the corresponding pyrazine triflates and substitution with primary or secondary amines led to 2-aminopyrazines. Since these syntheses take advantage of the use of readily available starting materials (e.g., amino acids, aminoalcohols and amines) a variety of the entitled structures can be obtained in few, high yielding steps.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b21ec400a6fea115aacf4e7c1f68449 https://doi.org/10.1055/s-2004-830866 Zobrazit plný text záznamu