Increased Risk of Ischemic Stroke in Young Patients with Ankylosing Spondylitis: A Population-Based Longitudinal Follow-Up Study

Autor: Shin-Liang Pan, Yu-Tsun Ho, Chia-Wei Lin, Ya-Ping Huang, Yueh-Hsia Chiu
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Male
Ankylosing Spondylitis
lcsh:Medicine
Vascular Medicine
Brain Ischemia
Brain ischemia
Medicine and Health Sciences
Longitudinal Studies
Prospective Studies
Young adult
lcsh:Science
Stroke
Multidisciplinary
Incidence (epidemiology)
Incidence
Middle Aged
Survival Rate
Neurology
Research Design
Female
Research Article
Adult
Risk
medicine.medical_specialty
Adolescent
Clinical Research Design
Cerebrovascular Diseases
Immunology
Research and Analysis Methods
Autoimmune Diseases
Young Adult
Internal medicine
medicine
Humans
Spondylitis
Ankylosing
Spondylitis
Survival rate
Ischemic Stroke
Ankylosing spondylitis
Health Care Policy
business.industry
lcsh:R
Biology and Life Sciences
Health Risk Analysis
medicine.disease
Health Care
Physical therapy
lcsh:Q
Clinical Immunology
business
Dyslipidemia
Follow-Up Studies
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e94027 (2014)
ISSN: 1932-6203
Popis: BACKGROUND: Prospective data on the association between ischemic stroke and ankylosing spondylitis (AS) in the young are sparse. The purpose of this population-based, age- and sex-matched longitudinal follow-up study was to investigate the risk of developing ischemic stroke in young patients with AS. METHODS: A total of 4562 patients aged 18- to 45-year-old with at least two ambulatory visits in 2001 with a principal diagnosis of AS were enrolled in the AS group. The non-AS group consisted of 22810 age- and sex-matched, randomly sampled subjects without AS. The two-year ischemic stroke-free survival rate for each group were calculated using the Kaplan-Meier method. Cox proportional hazards regression analysis was used to estimate the hazard ratio of ischemic stroke after adjusting for demographic and clinical covariates. RESULTS: During follow-up, 21 patients in the AS group and 53 in the non-AS group developed ischemic stroke. The ischemic stroke-free survival rate over the 2 year follow-up was lower in the AS group than the non-AS group (p = 0.0021). The crude hazard ratio of ischemic stroke for the AS group was 1.98 (95% CI, 1.20-3.29; p = 0.0079) and the adjusted hazard ratio after controlling for demographic and comorbid medical disorders was 1.93 (95% CI, 1.16-3.20; p = 0.0110). CONCLUSION: Our study showed an increased risk of developing ischemic stroke in young patients with AS.
Databáze: OpenAIRE
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