MiR-27a as a predictor for the activation of hepatic stellate cells and hepatitis B virus-induced liver cirrhosis
| Autor: | Shi-Bing Su, Shuang Huang, Xiu-Li Yan, Yi-Yu Lu, Yi-Yang Hu, Xin-Xin Guo, Lie-Ming Xu, Miao-Juan Shi, Qian-Mei Zhou, Qi-Long Chen, Hui Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Hepatitis B virus medicine.medical_specialty Cirrhosis hepatitis B virus-induced liver cirrhosis business.industry predictor FOXO1 MiR-27a medicine.disease_cause medicine.disease Gastroenterology 03 medical and health sciences Circulating MicroRNA 030104 developmental biology Oncology Internal medicine microRNA Hepatic stellate cell medicine In patient hepatic stellate cells business Research Paper Hepatic decompensation |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.23262 |
| Popis: | Circulating microRNAs (miRNAs) can be employed as biomarkers to diagnose liver and other diseases. Noninvasive approaches are needed to complement and improve the current strategies for screening for biomarkers liver cirrhosis. We determined whether the serum levels of miRNAs can distinguish between chronic hepatitis B (CHB) and CHB-induced cirrhosis (HBC) and investigated the potential mechanisms involved. We found that serum miR-27a was significantly up-regulated in HBC, distinguishing HBC from CHB and healthy controls (Ctrl) (P |
| Databáze: | OpenAIRE |
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