Initial endoscopic intervention is not associated with reduced risk of recurrent gastrointestinal bleeding in left ventricular assist device patients
| Autor: | Venkata Subhash Gorrepati, Benjamin Stern, John P. Boehmer, Parth Maheshwari, Deborah Bethards, Kofi Clarke, Jayakrishna Chintanaboina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Univariate analysis Gastrointestinal bleeding Multivariate analysis Surrogate endpoint business.industry medicine.medical_treatment Gastroenterology gastrointestinal bleeding Left ventricular assist device medicine.disease angioectasia Internal medicine Heart failure Ventricular assist device medicine Original Article Risk factor endoscopy business Destination therapy |
| Zdroj: | Annals of Gastroenterology |
| ISSN: | 1792-7463 1108-7471 |
| Popis: | Background Left ventricular assist devices (LVADs) are increasingly used for mechanical support of end-stage heart failure. Gastrointestinal bleeding (GIB) confers a significant morbidity in LVAD patients, with rates of up to 30% at 5 years. We assessed predictors of index and recurrent GIB (rGIB) in LVAD patients to risk stratify patients and evaluate if endoscopic approach and intervention at index GIB impacted rGIB. Methods A retrospective chart review of all LVAD patients at our institution from 01/01/2006 to 31/10/2016 was completed. Predictors for index and recurrent GIB were analyzed. Multivariate logistic regression analysis was created using only statistically significant dependent variables and adjusted for demographic variables. Results A total of 77/214 (36%) patients developed GIB, and 38/214 (17.8%) developed rGIB. Destination therapy (P=0.01), longer duration of LVAD (P=0.03), and low albumin ( |
| Databáze: | OpenAIRE |
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