Increased myocardial sodium signal intensity in Conn's syndrome detected by 23Na magnetic resonance imaging
| Autor: | Stefanie Hahner, Caroline Wörmann, Anne Scheffler, Bettina J Kraus, Thorsten Klink, Fabian Hammer, Bettina Geier, Leane Lehmann, Stefan Störk, Martin Christa, Herbert Köstler, Wolfgang R. Bauer, Andreas Max Weng, Johannes Oberberger |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Sodium chemistry.chemical_element Magnetic Resonance Imaging Cine 030204 cardiovascular system & hematology Essential hypertension Left ventricular hypertrophy Sodium Channels Muscle hypertrophy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Reference Values Internal medicine Hyperaldosteronism Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Aldosterone business.industry Myocardium Reproducibility of Results General Medicine Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Prognosis Blood pressure chemistry Case-Control Studies Cardiology Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine business |
| Zdroj: | European heart journal. Cardiovascular Imaging. 20(3) |
| ISSN: | 2047-2412 |
| Popis: | AIMS Sodium intake has been linked to left ventricular hypertrophy independently of blood pressure, but the underlying mechanisms remain unclear. Primary hyperaldosteronism (PHA), a condition characterized by tissue sodium overload due to aldosterone excess, causes accelerated left ventricular hypertrophy compared to blood pressure matched patients with essential hypertension. We therefore hypothesized that the myocardium constitutes a novel site capable of sodium storage explaining the missing link between sodium and left ventricular hypertrophy. METHODS AND RESULTS Using 23Na magnetic resonance imaging, we investigated relative sodium signal intensities (rSSI) in the heart, calf muscle, and skin in 8 PHA patients (6 male, median age 55 years) and 12 normotensive healthy controls (HC) (8 male, median age 61 years). PHA patients had a higher mean systolic 24 h ambulatory blood pressure [152 (140; 163) vs. 125 (122; 130) mmHg, P |
| Databáze: | OpenAIRE |
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