Bioresorbable Stent in Anterior Cruciate Ligament Reconstruction

Autor:	Jarosław Wieczorek, Krzysztof Ficek, Zygmunt Wróbel, Jolanta Rajca, Mateusz Stolarz, Stanislaw Blazewicz, Ewa Stodolak-Zych, Marek Wyleżoł, Marcin Binkowski, Małgorzata Muzalewska
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	medicine.medical_specialty X-ray microtomography Polymers and Plastics Anterior cruciate ligament reconstruction Anterior cruciate ligament medicine.medical_treatment 02 engineering and technology Osseointegration Article 03 medical and health sciences medicine Beneficial effects 030304 developmental biology 0303 health sciences Femoral tunnel business.industry anterior cruciate ligament reconstruction Stent X-raymicrotomography General Chemistry 021001 nanoscience & nanotechnology equipment and supplies musculoskeletal system Surgery medicine.anatomical_structure surgical procedures operative polylactide Bone tunnel bone tunnel enlargement 0210 nano-technology business human activities
Zdroj:	Polymers Volume 11 Issue 12
ISSN:	2073-4360
DOI:	10.3390/polym11121961
Popis:	The exact causes of failure of anterior cruciate ligament (ACL) reconstruction are still unknown. A key to successful ACL reconstruction is the prevention of bone tunnel enlargement (BTE). In this study, a new strategy to improve the outcome of ACL reconstruction was analyzed using a bioresorbable polylactide (PLA) stent as a catalyst for the healing process. The study included 24 sheep with 12 months of age. The animals were randomized to the PLA group (n = 16) and control group (n = 8), subjected to the ACL reconstruction with and without the implantation of the PLA tube, respectively. The sheep were sacrificed 6 or 12 weeks post-procedure, and their knee joints were evaluated by X-ray microcomputed tomography with a 50 &mu m resolution. While the analysis of tibial and femoral tunnel diameters and volumes demonstrated the presence of BTE in both groups, the enlargement was less evident in the PLA group. Also, the microstructural parameters of the bone adjacent to the tunnels tended to be better in the PLA group. This suggested that the implantation of a bioresorbable PLA tube might facilitate osteointegration of the tendon graft after the ACL reconstruction. The beneficial effects of the stent were likely associated with osteogenic and osteoconductive properties of polylactide.
Databáze:	OpenAIRE
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