Toxic Epidermal Necrolysis in Patients Receiving Anticonvulsants and Cranial Irradiation: A Risk to Consider
| Autor: | Roberto Pazo, Josefa Terrasa, David Aguiar, Herminio Manzano, Antonio Arrivi, Javier Martín, Julio Rifá, Ignacio Duran |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Phenytoin Cancer Research medicine.medical_specialty Lung Neoplasms Neurology medicine.medical_treatment Mucocutaneous zone Erythroderma Carcinoma Non-Small-Cell Lung Humans Medicine Risk factor Brain Neoplasms business.industry Middle Aged medicine.disease Dermatology Toxic epidermal necrolysis Surgery Radiation therapy stomatognathic diseases Anticonvulsant Oncology Stevens-Johnson Syndrome Anticonvulsants Neurology (clinical) Cranial Irradiation business medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 66:345-350 |
| ISSN: | 0167-594X |
| DOI: | 10.1023/b:neon.0000014538.31561.bc |
| Popis: | Toxic epidermal necrolysis (TEN) is an infrequent disease but with a high mortality rate. It is a mucocutaneous reaction resulting from hypersensitivity to a variety of agents including most anticonvulsants. Many patients with primary or metastatic intracranial tumours receive anticonvulsants for seizure prophylaxis despite their efficacy not having been clearly demonstrated. Moreover, several cases have been reported in the literature in which serious adverse drug reactions such as TEN and Stevens-Johnson syndrome (SJS) have occurred following anticonvulsants exposure. In some of these cases the effect of radiation therapy and the tapering of steroid dose on the pathogenesis of these reactions have been highlighted. We report, here, a case of TEN that appeared in a patient receiving phenytoin, and shortly after the end of cranial and thoracic irradiation therapy for brain metastases of non-small cell lung cancer. Clinical considerations about diagnosis of SJS and TEN are presented. The use of prophylactic anticonvulsants is also discussed as well as a review of the literature. |
| Databáze: | OpenAIRE |
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