Direct evidence for erythropoietin-induced release of endothelin from peripheral vascular tissue
| Autor: | Koichi Asahi, Soitsu Fukuchi, Daishiro Yamada, Kenji Mizuno, Ken Katoh, Shigeatsu Hashimoto, Koichiro Okazaki, Minoru Kuriki |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Prostaglandin Vasodilation 6-Ketoprostaglandin F1 alpha Biology General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley chemistry.chemical_compound Internal medicine medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics Erythropoietin Angiotensin II Endothelins General Medicine Endothelin 1 Recombinant Proteins Hindlimb Rats Thromboxane B2 Endocrinology medicine.anatomical_structure chemistry Blood Vessels Angiotensin I Endothelin receptor Blood vessel medicine.drug |
| Zdroj: | Life sciences. 54(16) |
| ISSN: | 0024-3205 |
| Popis: | The effect of recombinant human erythropoietin (r-HuEPO, 0.1 to 2.0 U/ml) on endothelin-1 (ET-1) release was examined in isolated hind legs perfused with Krebs-Ringer solution from normal rats. r-HuEPO increased immunoreactive (ir-) ET-1 release in a dose-dependent fashion; the maximal percent increment in ir-ET-1 release evoked by r-HuEPO (2.0 U/ml) was about +210% over the basal rate of release. However, r-HuEPO showed no effect on release of angiotensin II, thromboxane B2 or vasodilatory prostaglandin I2 from the vasculature. These results not only provide direct evidence that r-HuEPO has the potential to specifically stimulate release of ET-1 from peripheral vascular beds, but, hence, suggest a contributory role of ET-1 in r-HuEPO-induced hypertension in anemic human subjects undergoing r-HuEPO therapy. |
| Databáze: | OpenAIRE |
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