Comparison of a Hybrid IMRT/VMAT technique with non-coplanar VMAT and non-coplanar IMRT for unresectable olfactory neuroblastoma using the RayStation treatment planning system-EUD, NTCP and planning study
| Autor: | Tetsuo Akimoto, Masayuki Okumura, Takaki Ariji, Hidenobu Tachibana, Hajime Ohyoshi, Hidehiro Hojo, Shin-Ichiro Kageyama, Atsushi Motegi, Vijay Parshuram Raturi, Hidenari Hirata, Naoki Nakamura, Masaki Nakamura, Sadamoto Zenda, Toshiya Rachi, Yasuhiro Hirano, Kana Motegi |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Organs at Risk Time Factors equivalent uniform dose (EUD) Health Toxicology and Mutagenesis medicine.medical_treatment Nose Neoplasms Planning target volume normal tissue complication probability (NTCP) Esthesioneuroblastoma Olfactory 030218 nuclear medicine & medical imaging Oncology/Medicine 03 medical and health sciences Young Adult 0302 clinical medicine Planning study otorhinolaryngologic diseases Medicine Humans Radiology Nuclear Medicine and imaging intensity-modulated radiotherapy (IMRT) Radiation treatment planning neoplasms Aged Probability Aged 80 and over Radiation business.industry Radiotherapy Planning Computer-Assisted olfactory neuroblastoma (ONB) Dose-Response Relationship Radiation Middle Aged Equivalent uniform dose Radiation therapy stomatognathic diseases Integral dose 030220 oncology & carcinogenesis AcademicSubjects/SCI00960 Female Radiotherapy Intensity-Modulated AcademicSubjects/MED00870 Nasal Cavity business Nuclear medicine volumetric-modulated radiotherapy (VMAT) therapeutics Non coplanar Homogeneity index |
| Zdroj: | Journal of Radiation Research |
| ISSN: | 1349-9157 |
| Popis: | The purpose of this study was to compare hybrid intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (Hybrid IMRT/VMAT), with non-coplanar (nc) IMRT and nc-VMAT treatment plans for unresectable olfactory neuroblastoma (ONB). Hybrid IMRT/VMAT, nc-IMRT and nc-VMAT plans were optimized for 12 patients with modified Kadish C stage ONB. Dose prescription was 65 Gy in 26 fractions. Dose–volume histogram parameters, conformation number (CN), homogeneity index (HI), integral dose and monitor units (MUs) delivered per fraction were assessed. Equivalent uniform dose (EUD) and normal tissue complication probability (NTCP) based on the EUD model (NTCPLogit) and the Lyman–Kutcher–Burman model (NTCPLKB) were also evaluated. We found that the Hybrid IMRT/VMAT plan significantly improved the CN for clinical target volume (CTV) and planning treatment volume (PTV) compared with the nc-VMAT plan. In general, sparing of organs at risk (OARs) is similar with the three techniques, although the Hybrid IMRT/VMAT plan resulted in a significantly reduced Dmax to contralateral (C/L) optic nerve compared with the nc-IMRT plan. The Hybrid IMRT/VMAT plan significantly reduce EUD to the ipsilateral (I/L) and C/L optic nerve in comparison with the nc-IMRT plan and nc-VMAT plan, but the difference in NTCP between the three technique was |
| Databáze: | OpenAIRE |
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