Coded Aperture Raman Spectroscopy for Quantitative Measurements of Ethanol in a Tissue Phantom
| Autor: | Michael E. Gehm, Nikos P. Pitsianis, Scott T. McCain, David J. Brady, Yanqia Wang |
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| Rok vydání: | 2006 |
| Předmět: |
Etendue
Lipid Bilayers Analytical chemistry Spectrum Analysis Raman 01 natural sciences Light scattering 010309 optics Chemometrics symbols.namesake Optics 0103 physical sciences Partial least squares regression Combinatorial Chemistry Techniques Coded aperture Spectroscopy Instrumentation Ethanol Spectrometer business.industry Chemistry 010401 analytical chemistry Equipment Design 0104 chemical sciences Equipment Failure Analysis Refractometry symbols business Raman spectroscopy Algorithms |
| Zdroj: | Applied Spectroscopy. 60:663-671 |
| ISSN: | 1943-3530 0003-7028 |
| Popis: | Coded aperture spectroscopy allows for sources of large etendue to be efficiently coupled into dispersive spectrometers by replacing the traditional input slit with a patterned mask. We describe a coded aperture spectrometer optimized for Raman spectroscopy of diffuse sources, (e.g., tissue). We provide design details of the Raman system, along with quantitative estimation results for ethanol at non-toxic levels in a lipid tissue phantom. With 60 mW of excitation power at 808 nm, leave-one-out and blind cross-validation of partial least squares (PLS) regression models achieve r 2 . 0.98. Leave-one-out cross-validation demonstrates prediction errors of ,15% at the common legal limit for intoxication (17.4 mmol/L ¼ 0.08% by vol) and the best blind cross-validation achieves ,12% error at this concentration. Index Headings: Raman spectroscopy; Multiplexing; Chemometrics. |
| Databáze: | OpenAIRE |
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