Atorvastatin Downregulates Monocyte CD36 Expression, Nuclear NFκB and TNFα Levels in Type 2 Diabetes
| Autor: | Marco Rossetti, Luisa Lenti, Anna Carnovale, Emanuela Lococo, Alessandra Gatti, Elisabetta Mandosi, Susanna Morano, Sebastiano Filetti, Mara Fallarino, Barbara Buchetti |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
CD36 Antigens
Male medicine.medical_specialty Atorvastatin CD36 Down-Regulation Type 2 diabetes Protein Serine-Threonine Kinases Monocytes chemistry.chemical_compound Internal medicine Diabetes mellitus Internal Medicine medicine oxidative stress Humans Pyrroles diabetes statin therapy monocytes Scavenger receptor Cells Cultured Aged Inflammation medicine.diagnostic_test biology Tumor Necrosis Factor-alpha business.industry Anticholesteremic Agents Monocyte Biochemistry (medical) nutritional and metabolic diseases Middle Aged medicine.disease Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Cardiovascular Diseases Heptanoic Acids biology.protein Female lipids (amino acids peptides and proteins) Glycated hemoglobin Cardiology and Cardiovascular Medicine Lipid profile business medicine.drug |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 1880-3873 1340-3478 |
| DOI: | 10.5551/jat.2956 |
| Popis: | Aim: Type 2 diabetes increases the risk for cardiovascular disease, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) reduce cardiovascular events in these patients. The benefits of statin therapy cannot be explained only by the lipid-lowering effect. The aim of this study was to test the effect of atorvastatin therapy on CD36 scavenger receptor expression, nuclear factor-kappaB (NFκB) levels and markers of inflammation (C-reactive protein, CRP, Tumor Necrosis Factor-α, TNF-α) in circulating monocytes from diabetic patients.Methods: Twenty-two type 2 diabetic patients were treated for 8 weeks with atorvastatin (20 mg/day). At baseline and after treatment a blood sample was collected for measurement of glucose, lipid profile (total cholesterol, HDL, LDL cholesterol, triglycerides), glycated hemoglobin (HbA1c), CRP and for isolation of monocytes.Results: Atorvastatin decreased total (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|