Atorvastatin Downregulates Monocyte CD36 Expression, Nuclear NFκB and TNFα Levels in Type 2 Diabetes

Autor: Marco Rossetti, Luisa Lenti, Anna Carnovale, Emanuela Lococo, Alessandra Gatti, Elisabetta Mandosi, Susanna Morano, Sebastiano Filetti, Mara Fallarino, Barbara Buchetti
Rok vydání: 2010
Předmět:
CD36 Antigens
Male
medicine.medical_specialty
Atorvastatin
CD36
Down-Regulation
Type 2 diabetes
Protein Serine-Threonine Kinases
Monocytes
chemistry.chemical_compound
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
oxidative stress
Humans
Pyrroles
diabetes
statin therapy
monocytes
Scavenger receptor
Cells
Cultured
Aged
Inflammation
medicine.diagnostic_test
biology
Tumor Necrosis Factor-alpha
business.industry
Anticholesteremic Agents
Monocyte
Biochemistry (medical)
nutritional and metabolic diseases
Middle Aged
medicine.disease
Endocrinology
medicine.anatomical_structure
Diabetes Mellitus
Type 2
chemistry
Cardiovascular Diseases
Heptanoic Acids
biology.protein
Female
lipids (amino acids
peptides
and proteins)
Glycated hemoglobin
Cardiology and Cardiovascular Medicine
Lipid profile
business
medicine.drug
Zdroj: Scopus-Elsevier
ResearcherID
ISSN: 1880-3873
1340-3478
Popis: Aim: Type 2 diabetes increases the risk for cardiovascular disease, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) reduce cardiovascular events in these patients. The benefits of statin therapy cannot be explained only by the lipid-lowering effect. The aim of this study was to test the effect of atorvastatin therapy on CD36 scavenger receptor expression, nuclear factor-kappaB (NFκB) levels and markers of inflammation (C-reactive protein, CRP, Tumor Necrosis Factor-α, TNF-α) in circulating monocytes from diabetic patients.Methods: Twenty-two type 2 diabetic patients were treated for 8 weeks with atorvastatin (20 mg/day). At baseline and after treatment a blood sample was collected for measurement of glucose, lipid profile (total cholesterol, HDL, LDL cholesterol, triglycerides), glycated hemoglobin (HbA1c), CRP and for isolation of monocytes.Results: Atorvastatin decreased total (p
Databáze: OpenAIRE
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