Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool For Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis

Autor: Victoria Hans, Petra C E Hissink Muller, Annet van Royen-Kerkhof, Lauren M. Pachman, Femke van Wijk, Maria C. Amoruso, Esther P A H Hoppenreijs, Thaschawee Arkachaisri, Gabrielle A. Morgan, Wineke Armbrust, Kyra A. Gelderman, J. Merlijn van den Berg, Judith Wienke, Sylvia Kamphuis, Joo Guan Yeo
Přispěvatelé: Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Amsterdam institute for Infection and Immunity, Pediatrics
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Galectin 1
DISEASE-ACTIVITY
Polymyositis
Gastroenterology
Cohort Studies
0302 clinical medicine
Immunology and Allergy
Endothelial dysfunction
Child
Juvenile dermatomyositis
UNTREATED DISEASE
Endoglin
ALPHA MONOCLONAL-ANTIBODY
ASSOCIATION
Pediatric Rheumatology
Intercellular Adhesion Molecule-1
Prognosis
POLYMYOSITIS
Child
Preschool
Cohort
Biomarker (medicine)
Original Article
Female
Immunosuppressive Agents
Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5]
HIGH EXPRESSION
medicine.medical_specialty
Galectins
Immunology
MEMBRANE ATTACK COMPLEX
Dermatomyositis
03 medical and health sciences
Rheumatology
Internal medicine
medicine
Humans
Receptors
Tumor Necrosis Factor
Type II
Proportional Hazards Models
Inflammation
030203 arthritis & rheumatology
Duration of Therapy
Proportional hazards model
business.industry
MUSCLE-TISSUE
Endothelial Cells
IN-VITRO
medicine.disease
Chemokine CXCL13
GALECTIN-1
Chemokine CXCL10
030104 developmental biology
Chemokine CCL19
Endothelium
Vascular
Tumor necrosis factor receptor 2
business
Biomarkers
Zdroj: Arthritis & rheumatology (Hoboken, N.J.), 72(7), 1214-1226. John Wiley and Sons Ltd
ARTHRITIS & RHEUMATOLOGY, 72(7), 1214-1226. John Wiley & Sons Ltd.
Arthritis & Rheumatology, 72, 1214-1226
Arthritis & Rheumatology, 72(7), 1214-1226. Wiley
Arthritis & Rheumatology, 72, 7, pp. 1214-1226
Arthritis and Rheumatology, 72(7), 1214-1226. WILEY
Arthritis & Rheumatology (Hoboken, N.j.)
ISSN: 1529-0131
2326-5191
Popis: Contains fulltext : 220769.pdf (Publisher’s version ) (Open Access) OBJECTIVE: Juvenile dermatomyositis (DM) is a heterogeneous systemic immune-mediated vasculopathy. This study was undertaken to 1) identify inflammation/endothelial dysfunction-related biomarker profiles reflecting disease severity at diagnosis, and 2) establish whether such biomarker profiles could be used for predicting the response to treatment in patients with juvenile DM. METHODS: In total, 39 biomarkers related to activation of endothelial cells, endothelial dysfunction, and inflammation were measured using multiplex technology in serum samples from treatment-naive patients with juvenile DM from 2 independent cohorts (n = 30 and n = 29). Data were analyzed by unsupervised hierarchical clustering, nonparametric tests with correction for multiple comparisons, and Kaplan-Meier tests with Cox proportional hazards models for analysis of treatment duration. Myositis-specific antibodies (MSAs) were measured in the patients' serum using line blot assays. RESULTS: Severe vasculopathy in patients with juvenile DM was associated with low serum levels of intercellular adhesion molecule 1 (Spearman's rho [rs ] = 0.465, P = 0.0111) and high serum levels of endoglin (rs = -0.67, P < 0.0001). In the discovery cohort, unsupervised hierarchical clustering analysis of the biomarker profiles yielded 2 distinct patient clusters, of which the smaller cluster (cluster 1; n = 8) exhibited high serum levels of CXCL13, CCL19, galectin-9, CXCL10, tumor necrosis factor receptor type II (TNFRII), and galectin-1 (false discovery rate
Databáze: OpenAIRE
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