Similarity of coagulation and inflammation despite different surgical revascularization strategies – a prospective randomized trial
| Autor: | Markus Hoenicka, Andreas Kunert, K. Müller-Eising, H. Gorki, S. Deininger, P. Rupp, Andreas Liebold |
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| Rok vydání: | 2016 |
| Předmět: |
Advanced and Specialized Nursing
business.industry medicine.medical_treatment Extracorporeal circulation Antithrombin General Medicine 030204 cardiovascular system & hematology Revascularization 03 medical and health sciences 0302 clinical medicine Tissue factor pathway inhibitor medicine.anatomical_structure 030228 respiratory system Coagulation Anesthesia medicine Radiology Nuclear Medicine and imaging Platelet Cardiology and Cardiovascular Medicine business Safety Research Minimized extracorporeal circulation medicine.drug Artery |
| Zdroj: | Perfusion. 31:640-647 |
| ISSN: | 1477-111X 0267-6591 |
| DOI: | 10.1177/0267659116649426 |
| Popis: | Background: Supposedly, minimized extracorporeal circulation or off-pump revascularization as alternatives to conventional extracorporeal circulation (ONCAB) reduce inflammation and coagulation disturbances. Methods: One hundred and twenty coronary artery bypass graft (CABG) patients were prospectively randomized for three surgical techniques. Coagulation and inflammation markers were measured up to 72 hours postoperatively. Results: Coagulation factors I, II, V, X, antithrombin III and C-reactive protein did not differ perioperatively between the groups and increased, as did several other markers, 12 to 72 hours postoperatively. Compared to its alternatives, ONCAB showed the most obvious transient increase in thrombin-antithrombin complexes (pConclusions: With similarity in pivot coagulation factors, a specific detrimental influence of ONCAB on common coagulation pathways was excluded. Higher perioperative concentrations of products from the coagulation cascade most likely indicate activation of pericardial blood – recirculated only in ONCAB. Furthermore, with only temporary differences in markers of inflammation, the alternatives to ONCAB altogether were without advantage at 72 hours postoperatively. In the general answer to surgical trauma, the part of modern extracorporeal circulation is possibly overestimated. The study is registered at the German Clinical Trial Registry. Registration number DRKS00007580. URL: https://drks-neu.uniklinik-freiburg.de/drks_web/ URL: http://apps.who.int/trialsearch/ |
| Databáze: | OpenAIRE |
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