Spatial propagation of protein polymerization
| Autor: | Eugene M. Terentjev, Samuel I. A. Cohen, Tuomas P. J. Knowles, Alexander K. Buell, Christopher M. Dobson, Michele Vendruscolo, C. H. Yoon, David A. Weitz, Luke Rajah, Duncan A. White, Reisa A. Sperling |
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| Rok vydání: | 2013 |
| Předmět: |
Physics
Stochastic Processes Stochastic process Protein polymerization Monte Carlo method General Physics and Astronomy Proteins Observable Protein aggregation Polymerization Quantitative Biology::Subcellular Processes Diffusion Models Chemical Spatial evolution Statistical physics Diffusion (business) Spatial dependence Monte Carlo Method |
| Zdroj: | Physical review letters. 112(9) |
| ISSN: | 1079-7114 |
| Popis: | We consider the spatial dependence of filamentous protein self-assembly. Through studying the cases where the spreading of aggregated material is dominated either by diffusion or by growth, we derive analytical results for the spatial evolution of filamentous protein aggregation, which we validate against Monte Carlo simulations. Moreover, we compare the predictions of our theory with experimental measurements of two systems for which we identify the propagation as either growth or diffusion controlled. Our results connect the macroscopic observables that characterize the spatial propagation of protein self-assembly with the underlying microscopic processes and provide physical limits on spatial propagation and prionlike behavior associated with protein aggregation. |
| Databáze: | OpenAIRE |
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