Anti-Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults
| Autor: | Jean Marie Sueur, Jeanne Orfila, Fotini Betsou |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Microbiology (medical)
Adult Adolescent Immunology Molecular Sequence Data medicine.disease_cause Microbiology Immunoglobulin G Serology Immune system Seroepidemiologic Studies medicine Chaperonin 10 Immunology and Allergy Humans Chlamydiaceae Amino Acid Sequence Prospective Studies Aged Chlamydia biology General Medicine Chlamydophila pneumoniae Middle Aged medicine.disease biology.organism_classification Antibodies Bacterial Asthma respiratory tract diseases Infectious Diseases Humoral immunity biology.protein Antibody |
| Zdroj: | FEMS immunology and medical microbiology. 35(2) |
| ISSN: | 0928-8244 |
| Popis: | A multicenter prospective study was performed on 160 asthmatic adults suffering from acute episodes of bronchitis and 88 non-asthmatic controls, to investigate potential associations among Chlamydia pneumoniae infection and/or anti-C. pneumoniae heat shock protein 10 antibodies, and asthma. We used micro-immunofluorescence to detect serum anti-C. pneumoniae IgG, IgA and IgM antibodies and enzyme-linked immunosorbent assay to detect serum anti-Chsp10 peptide IgG antibodies. The serological prevalence of C. pneumoniae was 73.1%. An association was observed between the presence of anti-Chsp10 antibodies and adult onset asthma. The humoral immune responses were not confined to any particular region of the Chsp10 protein. |
| Databáze: | OpenAIRE |
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