Metabolism of drugs and other xenobiotics in the gut lumen and wall
| Autor: | Kenneth F. Ilett, Rodney F. Minchin, Lisa Tee, P.T. Reeves |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Lumen (anatomy)
Oxidative phosphorylation Biology Gut flora digestive system Xenobiotics Jejunum chemistry.chemical_compound In vivo medicine Animals Humans Pharmacology (medical) Intestinal Mucosa Pharmacology fungi digestive oral and skin physiology food and beverages Metabolism biology.organism_classification Bioavailability medicine.anatomical_structure chemistry Biochemistry Pharmaceutical Preparations Gastric Mucosa Xenobiotic Digestive System |
| Zdroj: | Pharmacologytherapeutics. 46(1) |
| ISSN: | 0163-7258 |
| Popis: | Metabolism in the gut lumen and wall can decrease the bioavailability and the pharmacological effects of a wide variety of drugs. Bacterial flora in the gut, the environmental pH and oxidative or conjugative enzymes present in the intestinal epithelial cells can all contribute to the process. Bacterial biotransformation is greatest in the colon, while gut wall metabolism is generally highest in the jejunum and decreases distally. Gut wall metabolism may be induced or inhibited by dietary or environmental xenobiotics or by co-administered drugs. Recent evidence suggests that some drugs, food-derived mutagens and other xenobiotics can be metabolized by gut flora and/or gut wall enzymes to reactive species which may cause tumors. |
| Databáze: | OpenAIRE |
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