Perturbations of the arginine metabolome following exposures to traffic-related air pollution in a panel of commuters with and without asthma
| Autor: | Douglas I. Walker, Chandresh Ladva, Donghai Liang, Karan Uppal, Rachel Golan, Stefanie Ebelt Sarnat, ViLinh Tran, Roby Greenwald, Armistead G. Russell, Jeremy A. Sarnat, Dean P. Jones, Tianwei Yu |
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| Rok vydání: | 2019 |
| Předmět: |
Traffic-Related Pollution
Future studies 010504 meteorology & atmospheric sciences Air pollution Transportation 010501 environmental sciences Arginine medicine.disease_cause 01 natural sciences Article Metabolomics Air Pollution Environmental health medicine Metabolome Humans lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science Asthma lcsh:GE1-350 Pollutant Cross-Over Studies Asthma exacerbations Traffic pollution business.industry medicine.disease Hospitalization business |
| Zdroj: | Environment International, Vol 127, Iss, Pp 503-513 (2019) |
| ISSN: | 0160-4120 |
| DOI: | 10.1016/j.envint.2019.04.003 |
| Popis: | Background: Mechanisms underlying the effects of traffic-related air pollution on people with asthma remain largely unknown, despite the abundance of observational and controlled studies reporting associations between traffic sources and asthma exacerbation and hospitalizations. Objectives: To identify molecular pathways perturbed following traffic pollution exposures, we analyzed data as part of the Atlanta Commuters Exposure (ACE-2) study, a crossover panel of commuters with and without asthma. Methods: We measured 27 air pollutants and conducted high-resolution metabolomics profiling on blood samples from 45 commuters before and after each exposure session. We evaluated metabolite and metabolic pathway perturbations using an untargeted metabolome-wide association study framework with pathway analyses and chemical annotation. Results: Most of the measured pollutants were elevated in highway commutes (p |
| Databáze: | OpenAIRE |
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