Effects of captopril on renal function in healthy uninephrectomized subjects and in healthy control subjects
| Autor: | Erling B. Pedersen, C. B. Nielsen |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Captopril Natriuresis Renal function Blood Pressure Lithium Nephrectomy Renal Circulation Renin-Angiotensin System chemistry.chemical_compound Atrial natriuretic peptide Heart Rate Internal medicine Internal Medicine medicine Humans Aldosterone business.industry Angiotensin II Middle Aged Filtration fraction Arginine Vasopressin Kidney Tubules Endocrinology chemistry Case-Control Studies Renal blood flow Potassium Female business Atrial Natriuretic Factor Glomerular Filtration Rate medicine.drug |
| Zdroj: | Journal of Internal Medicine. 235:359-365 |
| ISSN: | 1365-2796 0954-6820 |
| DOI: | 10.1111/j.1365-2796.1994.tb01087.x |
| Popis: | Objectives. To study the importance of the reninangiotensin-II system for renal haemodynamics and sodium and water handling in the adapted remnant kidney in healthy uninephrectomized subjects. Design. Case-control study. Setting. All subjects were investigated at laboratory C, Department of Medicine and Nephrology, Skejby Hospital. Subjects. Fourteen healthy uninephrectomized (Unx) and 14 matched healthy control subjects (Cs). Intervention. Captopril, 25 mg orally. Main outcome measures. The glomerular filtration rate (GFR) and renal plasma flow (RPF) were measured by the constant infusion clearance technique using 125I-iothalamate and 131I-hippuran as reference substances, tubular function was evaluated by the lithium clearance technique (CLi), urinary flow rate (V), sodium excretion (UNaV), fractional sodium excretion (FENa), mean blood pressure (MBP) and heart rate (HR) were measured by conventional methods and plasma levels of angiotensin II (Ang-II), aldosterone (Aldo), arginine vasopressin (AVP) and atrial natriuretic peptide (ANP) were measured by radioimmunoassay. Results. In both groups captopril ingestion resulted in a significant decrease in the MBP (Unx: 87.1 to 83.5 and Cs: 86.8 to 83.8 mmHg, median values), filtration fraction (Unx: 24.6 to 22.1 and Cs: 24.1 to 22.5%, median values) and Ang-II (Unx: 10.5 to 7.7 and Cs: 12 to 7.6 pmol-1. median values). Single kidney GFR, V, and CLi were unchanged in both groups. FENa and single kidney RPF were significantly increased in only the Cs group; FENa (Unx: 1.81 to 1.91 and Cs: 1.56 and 1.90%, median values). The plasma level of ANP was significantly decreased in only the Unx group. Conclusion. The data suggest that sodium handling in the remnant kidney in uninephrectomized subjects could be less sensitive to Ang-II than in healthy control subjects, and that this might be as a result of adaptive changes in the distal parts of the nephron. |
| Databáze: | OpenAIRE |
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