Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection
| Autor: | Caio Vinicius Botelho Brito, Érika Dayane Leal Rodrigues, Fernanda Monik Silva Martins, Lavinia Dias Tavares, André Luis de Sousa Nogueira Lima, Lucas Carvalho Ferreira, Carlos Junior Lopes Santana, João Augusto Gomes de Souza Monteiro de Brito, Lívia Medeiros Neves Casseb, José Antonio Picanço Diniz Junior |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Central Nervous System
Rabies RC955-962 030231 tropical medicine Biopterin Context (language use) Blood–brain barrier medicine.disease_cause Interleucina-6 Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Barreira Hematoencef?lica Arctic medicine. Tropical medicine Sistema Nervoso Central / efeitos dos f?rmacos medicine Animals Humans Cytotoxic T cell Raiva / patologia Tetrahydrobiopterin Biopterina business.industry Interleukin-6 Rabies virus Brain medicine.disease Disease Models Animal medicine.anatomical_structure chemistry Blood-Brain Barrier V?rus da Raiva / patogenicidade Immunology Original Article business medicine.drug |
| Zdroj: | Revista do Instituto de Medicina Tropical de São Paulo; Vol. 63 (2021); e28 Revista do Instituto de Medicina Tropical de São Paulo; v. 63 (2021); e28 Revista do Instituto de Medicina Tropical de São Paulo Instituto de Medicina Tropical (IMT) instacron:IMT Revista do Instituto de Medicina Tropical de São Paulo, Volume: 63, Article number: e28, Published: 12 APR 2021 Revista do Instituto de Medicina Tropical de São Paulo, Vol 63 (2021) Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC |
| ISSN: | 1678-9946 0036-4665 |
| Popis: | Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de P?s-Gradua??o em Virologia. Ananindeua, PA, Brasil. Universidade Federal do Par?. Programa de Biologia e Agente Infeciosos e Parasit?rios. Ananindeua, PA, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de Inicia??o Cient?fica. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de Inicia??o Cient?fica. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de Inicia??o Cient?fica. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de Inicia??o Cient?fica. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de Inicia??o Cient?fica. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Programa de Inicia??o Cient?fica. Ananindeua, PA, Brasil. Universidade do Estado do Par?. Faculdade de Medicina. Bel?m, PA, Brazil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells. |
| Databáze: | OpenAIRE |
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