Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats
| Autor: | Yeon Ju Park, Young-Rae Lee, Yang Gyu Kang, Deuk Seon Park, Sang-Hoon Park, Dae In Moon, Young Pill Kim, Hak Yong Lee, Okjin Kim, Oh Hong Geun, Hyang Man Lee, Hye-Jeong Yang, Min Jung Kim, Bong Gun Lee, Young Mi Park |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
immunosuppressed rats medicine.medical_treatment spleonocyte Immunology Spleen Pharmacology 01 natural sciences Proinflammatory cytokine 0404 agricultural biotechnology Immune system Oral administration In vivo medicine Splenocyte cytokine immunostimulation lcsh:Agriculture (General) Chemistry 010401 analytical chemistry 04 agricultural and veterinary sciences 040401 food science lcsh:S1-972 In vitro 0104 chemical sciences medicine.anatomical_structure Cytokine portulaca oleracea l lcsh:RC581-607 Agronomy and Crop Science Food Science |
| Zdroj: | Food and Agricultural Immunology, Vol 30, Iss 1, Pp 13-24 (2019) |
| ISSN: | 1465-3443 0954-0105 |
| Popis: | Portulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE exerted an immunostimulatory effect in vivo and in vitro. Specifically, PPCE significantly enhanced splenocyte proliferation and upregulated inflammatory cytokines (IL-2, IL-12, TNF-α, and IFN-γ) and NK cell activity in vitro. The immunostimulatory effect was further investigated through various immunological assays. Oral administration of PPCE increased the swimming time and number of immune cells in rats. Histological analysis revealed that PPCE administration exerted splenic recovery. Thus, P. oleracea L. based complex extracts may be used as an immunostimulatory agent in medicine or functional foods. |
| Databáze: | OpenAIRE |
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