Development of a unified clinical trial database for Alzheimer's disease
| Autor: | Diane Stephenson, Lisa J. Bain, Robert Stafford, Enrique Aviles, Steve Broadbent, Klaus Romero, Steve Kopko, Jon Neville, Christine M. Solinsky, Martin Cisneroz |
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| Rok vydání: | 2014 |
| Předmět: |
Databases
Factual Epidemiology Pooling Decision Making Statistics as Topic Disease Information repository computer.software_genre Cellular and Molecular Neuroscience Cognition Developmental Neuroscience Alzheimer Disease Medicine Humans Clinical Trials as Topic Internet Database business.industry Health Policy Reference Standards Clinical trial Psychiatry and Mental health Drug development Neurology (clinical) Disease assessment Geriatrics and Gerontology business computer Data integration |
| Zdroj: | Alzheimer'sdementia : the journal of the Alzheimer's Association. 11(10) |
| ISSN: | 1552-5279 |
| Popis: | Introduction Data obtained in completed Alzheimer's disease (AD) clinical trials can inform decision making for future trials. Recognizing the importance of sharing these data, the Coalition Against Major Diseases created an Online Data Repository for AD (CODR-AD) with the aim of supporting accelerated drug development. The aim of this study was to build an open access, standardized database from control arm data collected across many clinical trials. Methods Comprehensive AD-specific data standards were developed to enable the pooling of data from different sources. Nine member organizations contributed patient-level data from 24 clinical trials of AD treatments. Results CODR-AD consists of control arm pooled and standardized data from 24 trials currently numbered at 6500 subjects; Alzheimer's Disease Assessment Scale-cognitive subscale 11 is the main outcome and specific covariates are also included. Discussion CODR-AD represents a unique integrated standardized clinical trials database available to qualified researchers. The pooling of data across studies facilitates a more comprehensive understanding of disease heterogeneity. |
| Databáze: | OpenAIRE |
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