Reactive oxygen species and yeast apoptosis
Autor: | Shi-Xiong Tan, Ian W. Dawes, Gabriel G. Perrone |
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Rok vydání: | 2008 |
Předmět: |
Programmed cell death
Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Apoptosis Biology Mitochondrion Endoplasmic Reticulum medicine.disease_cause Antioxidants medicine Molecular Biology Actin Cytoskeleton chemistry.chemical_classification Reactive oxygen species Stress responses Cell Biology biology.organism_classification Yeast Actins Mitochondria Cell biology Biochemistry chemistry Oxidative stress Metals Apoptosis Regulatory Proteins Reactive Oxygen Species DNA Damage Transcription Factors |
Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1783:1354-1368 |
ISSN: | 0167-4889 |
Popis: | Apoptosis is associated in many cases with the generation of reactive oxygen species (ROS) in cells across a wide range of organisms including lower eukaryotes such as the yeast Saccharomyces cerevisiae. Currently there are many unresolved questions concerning the relationship between apoptosis and the generation of ROS. These include which ROS are involved in apoptosis, what mechanisms and targets are important and whether apoptosis is triggered by ROS damage or ROS are generated as a consequence or part of the cellular disruption that occurs during cell death. Here we review the nature of the ROS involved, the damage they cause to cells, summarise the responses of S. cerevisiae to ROS and discuss those aspects in which ROS affect cell integrity that may be relevant to the apoptotic process. |
Databáze: | OpenAIRE |
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