Innovative trends and perspectives for erectile dysfunction treatment: A systematic review
| Autor: | Ezzat A. Ismail, Ahmed I. El-Sakka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
FDA
USA Food and Drug Administration Urology VEGF receptors 030232 urology & nephrology Stem cells Pharmacology Nitric oxide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine VED vacuum erectile device Herbal treatment ADSCs adipose tissue-derived stem cells medicine cNOS constitutive nitric oxide synthase Erectile dysfunction ED erectile dysfunction PDE5 inhibitors Cyclic guanosine monophosphate NO nitric oxide Shockwave therapy (hUCB-)MSCs (human umbilical cord blood) mesenchymal stem cells 030219 obstetrics & reproductive medicine biology business.industry PDE5Is phosphodiesterase type 5 inhibitors Andrology/Sexual Medicine Review medicine.disease RP radical prostatectomy VEGF vascular endothelial growth factor SC stem cell Phosphodiesterase Type 5 Inhibitors Vascular endothelial growth factor ICI intracavernosal injection chemistry cGMP cyclic guanosine monophosphate biology.protein sGC soluble guanylate cyclase LI-ESWT low-intensity extracorporeal shockwave therapy Stem cell business |
| Zdroj: | Arab Journal of Urology |
| ISSN: | 2090-598X |
| DOI: | 10.1016/j.aju.2016.04.002 |
| Popis: | Objective To review contemporary knowledge concerning the innovative trends and perspectives in the treatment of erectile dysfunction (ED). Methods Medline was reviewed for English-language journal articles between January 2000 and March 2016, using the terms ‘erectile dysfunction treatments’, ‘new trends’ and ‘perspectives’. In all, 114 original articles and 16 review articles were found to be relevant. Of the 76 cited papers that met the inclusion criteria, 51 papers had level of evidence of 1a–2b, whilst 25 had level of evidence of 3–4. Criteria included all pertinent review articles, randomised controlled trials with tight methodological design, cohort studies, and retrospective analyses. We also manually reviewed references from selected articles. Results Several interesting studies have addressed novel phosphodiesterase type 5 inhibitors (PDE5Is), orodispersible tablets, their recent chronic use, and combination with other agents. A few controlled studies have addressed herbal medicine as a sole or additional treatment for ED. Experimental studies and exciting review papers have addressed stem cells as novel players in the field of ED treatment. Other recent articles have revised the current status of low-intensity extracorporeal shockwave therapy in the field of ED. A few articles without long-term data have addressed new technologies that included: external penile support devices, penile vibrators, tissue engineering, nanotechnology, and endovascular tools for ED treatment. Conclusions The current treatment of ED is still far from ideal. We expect to see new drugs and technologies that may revolutionise ED treatment, especially in complex cases. |
| Databáze: | OpenAIRE |
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