Sex effects on clinical features in LRRK2 G2385R carriers and non-carriers in Parkinson's disease

Autor: Sheng-Di Chen, Chao Gao, Juan-Juan Du, Shi-Shuang Cui, Yi-Qi Lin, Pei Huang, Hai-Yan Zhou, Rao Fu
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Heterozygote
Activities of daily living
Movement disorders
Parkinson's disease
Genotype
LRRK2 G2385R
Excessive daytime sleepiness
Disease
Lower risk
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
030304 developmental biology
Aged
0303 health sciences
Sex Characteristics
business.industry
General Neuroscience
lcsh:QP351-495
Patient Acuity
Parkinson Disease
Middle Aged
medicine.disease
LRRK2
nervous system diseases
lcsh:Neurophysiology and neuropsychology
Mood disorders
Clinical feature
Mutation
Transcranial sonographic
Parkinson’s disease
Female
Sex
medicine.symptom
business
030217 neurology & neurosurgery
Research Article
Zdroj: BMC Neuroscience
BMC Neuroscience, Vol 22, Iss 1, Pp 1-7 (2021)
ISSN: 1471-2202
Popis: Background Differences of genotypes between male and female have been studied in Parkinson’s disease (PD), but limited research has focused on the comparison between sexes with LRRK2 G2385 variant. Objective The aim of this study was to explore sex effects in the same genetic subtype and role of leucine-rich repeat kinase 2 (LRRK2) G2385R variants in the same sex in PD. Methods 613 PD patients were recruited from the Movement Disorders Clinic in Ruijin Hospital. We did not include healthy controls in this study. The data collected includes demographic information, disease history, scores of motor and non-motor symptoms scales, midbrain transcranial sonography and DNA. Binary logistic regression analysis was performed to evaluate the association between clinical features and sex in LRRK2 G2385R carriers and non-carriers, as well as the association between the clinical features and LRRK2 G2385R variants in male and female sex. Results Sex distribution is similar in LRRK2 G2385R carriers and non-carriers. In male sex, LRRK2 G2385R carriers showed lower risk in cognitive impairment compared with non-carriers (OR = 0.301, p = 0.003, 95%CI 0.135–0.668). In female sex, LRRK2 G2385R carriers showed lower risk in autonomic dysfunction compared with non-carrier (OR = 0.401, p = 0.040, 95%CI 0.167–0.960). In LRRK2 G2385R non-carriers, female sex showed lower risk of impairment in activity of daily living (OR = 0.610, p = 0.021, 95%CI 0.400–0.928), excessive daytime sleepiness (OR = 0.555, p = 0.007, 95%CI 0.361–0.853), substantia nigra hyperechogenicity (OR = 0.448, p = 0.019, 95%CI 0.228–0.878), autonomic dysfunction frequency (OR = 0.626, p = 0.016, 95%CI 0.428–0.917) and higher risk in mood disorders (OR = 1.691, p = 0.022, 95%CI 1.078–2.654) compared with male. In LRRK2 G2385R carriers, female sex showed a lower risk of autonomic dysfunction (OR = 0.294, p = 0.024, 95%CI 0.102–0.849) compared with male. Conclusion In contrast to male PD patients, a more benign disease course was observed in female in both LRRK2 G2385R carriers and non-carriers. However, sex differences were less notable in PD with LRRK2 G2385R variants.
Databáze: OpenAIRE
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