The prevalence of anticitrullinated protein antibodies in older Poles-results from a population-based PolSenior study
| Autor: | Anna Chudek, Przemysław Kotyla, Małgorzata Mossakowska, Tomasz Grodzicki, Tomasz Zdrojewski, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek, Aleksander J. Owczarek |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Aged
80 and over Male older adults anti-CPP prevalence rheumatoid arthritis ACPA anticitrullinated protein antibodies Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Prevalence Humans Female Peptides Cyclic Anti-Citrullinated Protein Antibodies Hypoalbuminemia Aged Autoantibodies |
| Zdroj: | International Journal of Environmental Research and Public Health; Volume 19; Issue 21; Pages: 14216 |
| Popis: | Little is known about the occurrence of antibodies in older subjects. We analyzed the prevalence of anticitrullinated protein antibodies (anti-CCP) in a representative cohort of Polish older adults, participants of PolSenior substudy. Randomly selected 1537 serum samples of community-dwelling participants aged 65 and over. Questionnaires were completed by qualified interviewers and laboratory assessments served as a database for this analysis. The frequency of anti-CCP seropositivity (N = 50) was estimated at 3.25% (95% CI: 2.45–4.30%), being higher among women—4.05% (2.83–5.73%) than men—2.41% (1.48–3.86%). The frequency of anti-CCP seropositivity was decreasing with age from 4.29% in aged 65–74 years and 4.07% in 70–84 years to 1.50% in aged 85 years or above (p < 0.05). Hypoalbuminemia, inflammatory status (C-reactive protein >10 mg/dL or interleukin-6 ≥10 pg/mL), and female gender were associated with increased, while age ≥85 years with decreased risk of seropositivity. Multivariable logistic regression revealed that hypoalbuminemia, inflammatory status, and age ≥85 years were independently associated factors of anti-CCP seropositivity. The decreased frequency of anti-CCP seropositivity in the oldest old suggests shorter survival of the seropositive individuals who developed rheumatoid arthritis. It seems that low symptomatic RA remains frequently undiagnosed in older subjects. |
| Databáze: | OpenAIRE |
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