Fertility in patients treated for testicular cancer
| Autor: | Breda Škrbinc, Branko Zakotnik, Erika Matos |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty endocrine system diseases Adolescent media_common.quotation_subject medicine.medical_treatment Fertility Reproductive age Antineoplastic Agents urologic and male genital diseases Retroperitoneal lymph node dissection Young Adult Testicular Neoplasms Risk Factors Surveys and Questionnaires Medicine Humans In patient Retroperitoneal Space Survivors Testicular cancer Infertility Male media_common Gynecology Chemotherapy Radiotherapy urogenital system Oncology (nursing) business.industry medicine.disease Combined Modality Therapy Seminoma Radiation therapy Sexual Dysfunction Physiological Oncology Quality of Life Lymph Node Excision business Orchiectomy After treatment |
| Zdroj: | Journal of cancer survivorship : research and practice. 4(3) |
| ISSN: | 1932-2267 |
| Popis: | Testicular cancer affects men mostly in their reproductive age with a cure rate over 90% and fertility is one of the main concerns of survivors. To further elucidate the question of fertility after treatment for testicular cancer, we performed a survey in patients treated in our institution.We sent a questionnaire to patients treated for testicular cancer at our institute from 1976 to 2002 (n = 490) of whom 297 (60.6%) responded. We considered the patients to have conserved fertility if they had children after treatment without assisted reproductive technologies.Before treatment 119/297 (40.1%) of patients and after treatment 150/297 (50.5%) of patients tried to have children (p = 0.019). Of 119 patients who tried to have children before treatment for testicular cancer 98 (82.4%) succeeded and 74/150 (49.3%) were successful after treatment (p0.001). After treatment patients had 1-3 (median 1) children. The median time to birth of first child from diagnosis was 12 years. The post-treatment fatherhood in patients treated with surgery only (orchidectomy +/- retroperitoneal lymphnode dissection-RPLND) was 59%, in those with additional radiotherapy 68%, and chemotherapy 50% (p = 0.233). Fertility rate in patients where a non nerve sparing RPLND was performed was only 37%, 62% in patients with nerve sapring RPLND, and 77% in patients where RPLND was not performed (p0.0001).Fertility rate after treatment for testicular cancer is reduced. From our data, the most important treatment modality that influences fertility is non nerve sparing RPLND that should be avoided whenever possible in order improve the quality of life our patients. |
| Databáze: | OpenAIRE |
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