Multifunctional 3D-Printed Wound Dressings
| Autor: | Nancy Khuu, Daniel Pinto Ramos, Shana O. Kelley, Eugenia Kumacheva, Moien Alizadehgiashi, Sharif Uddin Ahmed, Nitesh Mittal, Mahshid Chekini, Carine R. Nemr |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
Wound site 3d printed Silver Personalized treatment Metal Nanoparticles General Physics and Astronomy 02 engineering and technology 010402 general chemistry 01 natural sciences Silver nanoparticle Mice medicine Animals General Materials Science integumentary system Chemistry General Engineering Granulation tissue Hydrogels 021001 nanoscience & nanotechnology Bandages Controlled release Physiological responses Anti-Bacterial Agents 0104 chemical sciences medicine.anatomical_structure Printing Three-Dimensional Drug delivery 0210 nano-technology Biomedical engineering |
| Zdroj: | ACS Nano. 15:12375-12387 |
| ISSN: | 1936-086X 1936-0851 |
| DOI: | 10.1021/acsnano.1c04499 |
| Popis: | Personalized wound dressings provide enhanced healing for different wound types; however multicomponent wound dressings with discretely controllable delivery of different biologically active agents are yet to be developed. Here we report 3D-printed multicomponent biocomposite hydrogel wound dressings that have been selectively loaded with small molecules, metal nanoparticles, and proteins for independently controlled release at the wound site. Hydrogel wound dressings carrying antibacterial silver nanoparticles and vascular endothelial growth factor with predetermined release profiles were utilized to study the physiological response of the wound in a mouse model. Compared to controls, the application of dressings resulted in improvement in granulation tissue formation and differential levels of vascular density, dependent on the release profile of the growth factor. Our study demonstrates the versatility of the 3D-printed hydrogel dressings that can yield varied physiological responsesiin vivo/iand can further be adapted for personalized treatment of various wound types. |
| Databáze: | OpenAIRE |
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