Oral Gram-negative anaerobic bacilli as a reservoir of β-lactam resistance genes facilitating infections with multiresistant bacteria
| Autor: | Zohreh Tamanai-Shacoori, Anne Jolivet-Gougeon, Clarisse Dupin, Frédérique Barloy-Hubler, Latifa Bousarghin, Anais Dupont, Elodie Ehrmann, Martine Bonnaure-Mallet |
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| Přispěvatelé: | CHU Pontchaillou [Rennes], Microbiologie : Risques Infectieux, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Faculté de Chirurgie Dentaire de Rennes-Faculté d'Odontologie-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Nice (CHU Nice), Institut de Génétique et Développement de Rennes (IGDR), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes (UR)-CHU Pontchaillou [Rennes]-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Université de Rennes - UFR d'Odontologie (UR Odontologie), Université de Rennes (UR)-Université de Rennes (UR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Bacilli [SDV]Life Sciences [q-bio] Prevotella beta-Lactams Integron Microbiology 03 medical and health sciences Plasmid Drug Resistance Multiple Bacterial Humans Pharmacology (medical) β-Lactamase Disease Reservoirs 030304 developmental biology Mouth 0303 health sciences Gram-Negative Anaerobic Bacteria biology 030306 microbiology Biofilm General Medicine biology.organism_classification Capnocytophaga stomatognathic diseases Infectious Diseases Fusobacterium Genes Bacterial cfxA biology.protein Fusobacterium nucleatum Mobile genetic elements Gram-Negative Bacterial Infections |
| Zdroj: | International Journal of Antimicrobial Agents International Journal of Antimicrobial Agents, Elsevier, 2015, 45 (2), pp.99-105. ⟨10.1016/j.ijantimicag.2014.10.003⟩ International Journal of Antimicrobial Agents, 2015, 45 (2), pp.99-105. ⟨10.1016/j.ijantimicag.2014.10.003⟩ |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2014.10.003⟩ |
| Popis: | International audience; Many β-lactamases have been described in various Gram-negative bacilli (Capnocytophaga, Prevotella, Fusobacterium, etc.) of the oral cavity, belonging to class A of the Ambler classification (CepA, CblA, CfxA, CSP-1 and TEM), class B (CfiA) or class D in Fusobacterium nucleatum (FUS-1). The minimum inhibitory concentrations of β-lactams are variable and this variation is often related to the presence of plasmids or other mobile genetic elements (MGEs) that modulate the expression of resistance genes. DNA persistence and bacterial promiscuity in oral biofilms also contribute to genetic transformation and conjugation in this particular microcosm. Overexpression of efflux pumps is facilitated because the encoding genes are located on MGEs, in some multidrug-resistant clinical isolates, similar to conjugative transposons harbouring genes encoding β-lactamases. All these facts lead us to consider the oral cavity as an important reservoir of β-lactam resistance genes and a privileged place for genetic exchange, especially in commensal strictly anaerobic Gram-negative bacilli. |
| Databáze: | OpenAIRE |
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