Weight change, weight cycling and mortality in the ERFORT Male Cohort Study
| Autor: | Peter Rzehak, Gabriele Woelke, Sabine Brasche, Christa Meisinger, Gert Strube, Joachim Heinrich |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Gerontology Epidemiology Population Health Behavior Medicine (miscellaneous) Weight Gain Cohort Studies Risk Factors Weight loss Cause of Death Germany Weight Loss gender cohort study medicine Humans Obesity Prospective Studies Mortality education Prospective cohort study Aged weight cycling education.field_of_study Nutrition and Dietetics business.industry weight change Body Weight Weight change Hazard ratio Weight Fluctuation Middle Aged ddc: 610 Cohort medicine.symptom business Weight gain Demography Cohort study |
| Zdroj: | Kongress Medizin und Gesellschaft 2007; 20070917-20070921; Augsburg; DOC07gmds339 /20070906/ |
| ISSN: | 1573-7284 0393-2990 |
| Popis: | Objective To investigate the effect of weight change and weight fluctuations on all-cause-mortality in men. Methods Within a prospective population-based cohort of 1160 men aged 40–59 years at recruitment, complete weight change patterns from baseline and three follow-up examinations during a period of 15 years of follow-up was used to categorize the 505 men into stable obese, stable non-obese, weight gain, weight loss and weight fluctuation groups. For these men (age range: 55–74 years at start time of survival analysis) further survival was analyzed during the subsequent 15 years. Results Overall, 183 deaths were observed among the 505 men. Only weight fluctuations had a clear significant impact on all-cause mortality. Adjusted hazard rate ratio (HRR (95%-CI)) was 1.86 (1.31–2.66) after adjustment for age group, pre-existing cardiovascular disease or diabetes mellitus, smoking and socio-economic status. The risk rate due to weight loss was borderline significant (HRR = 1.81 (0.99–3.31)). Risk of death due to weight gain (HRR = 1.15 (0.70–1.88)) or stable obesity (HRR = 1.16 (0.69–1.94)), however, were not significantly increased compared to men staying non-obese for the first 15 years after cohort recruitment. Conclusion Weight fluctuations are a major risk factor for all-cause mortality in middle aged men. Moreover, stable obesity does not increase further mortality in men aged 55–74 years in long-term follow-up. |
| Databáze: | OpenAIRE |
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