Natural killer cells in human autoimmune disorders
| Autor: | Leslie A. Fogel, Anthony R. French, Wayne M. Yokoyama |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Chemokine
medicine.medical_specialty Immunology Autoimmunity Review Lymphocyte Activation medicine.disease_cause Autoimmune Diseases 03 medical and health sciences 0302 clinical medicine Immune system Rheumatology Internal medicine medicine Humans Immunology and Allergy 030304 developmental biology 0303 health sciences biology Multiple sclerosis Innate lymphoid cell medicine.disease 3. Good health Killer Cells Natural Cytolysis Rheumatoid arthritis biology.protein 030215 immunology |
| Zdroj: | Arthritis Research & Therapy |
| ISSN: | 1478-6354 |
| DOI: | 10.1186/ar4232 |
| Popis: | Natural killer (NK) cells are innate lymphocytes that play a critical role in early host defense against viruses. Through their cytolytic capacity and generation of cytokines and chemokines, NK cells modulate the activity of other components of the innate and adaptive immune systems and have been implicated in the initiation or maintenance of autoimmune responses. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in T-cell and B-cell-mediated autoimmune disorders in humans, with a particular focus on multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematous. A better understanding of the contributions of NK cells to the development of autoimmunity may lead to novel therapeutic targets in these diseases. |
| Databáze: | OpenAIRE |
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