Is Metoclopramide an Alternative to Tramadol in Management of Post-operative Pain? An Experimental Study*
| Autor: | T. Ide, N. Unal, Kemal Altunatmaz, H. Üstün, A. Ceyhan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Metoclopramide medicine.medical_treatment Plantar surface Pathology and Forensic Medicine Rats Sprague-Dawley Male rats Animals Medicine Saline Tramadol Pain Measurement Pain Postoperative General Veterinary business.industry Significant difference Rats Surgery Analgesics Opioid Treatment Outcome Anesthesia Dopamine Antagonists business Surgical incision Post operative pain medicine.drug |
| Zdroj: | Journal of Veterinary Medicine Series A. 52:249-253 |
| ISSN: | 1439-0442 0931-184X |
| DOI: | 10.1111/j.1439-0442.2005.00719.x |
| Popis: | In this study, metoclopramide was compared with other pharmacological agents for preventing post-operative pain. Sixty Sprague-Dawley male rats, weighing 310-345 g were included in the study; 1 cm surgical incision, including skin, facia, and muscle was made to the plantar surface of rear foot of all anaesthetized rats. Rats were randomized into four groups. In group 1 (group S) 2 cm3 saline, in group 2 (group M) 2 cm3 metoclopramide (5 mg/kg) in group 3 (group T) 2 cm3 tramadol (45 mg/kg), in group 4 (group M+T) half doses of group M and group T was given intraperitoneally. Post-operative pain was assessed after 2 h, first and second days of incision. Post-operative pain scores were found to be significantly lower in group M, group T and group M+T when compared with the control group. But there was no significant difference between these groups. We concluded that metoclopramide, with low cost, fewer side-effects and being significantly effective for preventing post-operative pain, can be an alternative to tramadol. |
| Databáze: | OpenAIRE |
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