Chronic lung disease in premature infants: a retrospective evaluation of underlying factors
| Autor: | John P. Grausz, Robert J. Starshak, P. Sasidharan, Ruth Heimler, Raymond G. Hoffmann |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Artificial ventilation
Male congenital hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Critical Care medicine.medical_treatment Birth weight Gestational Age Critical Care and Intensive Care Medicine Intermittent Positive-Pressure Ventilation Ductus arteriosus medicine Birth Weight Humans Bronchopulmonary Dysplasia Retrospective Studies business.industry Respiratory disease Infant Newborn Gestational age Retrospective cohort study respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure Bronchopulmonary dysplasia Anesthesia Chronic Disease Apgar Score Apgar score Female business |
| Zdroj: | Critical care medicine. 16(12) |
| ISSN: | 0090-3493 |
| Popis: | A retrospective case-control study involving 99 premature infants requiring vigorous respiratory support was conducted to investigate the relative contribution of various etiologic factors in the development of chronic lung disease (CLD). Nineteen of the 99 developed CLD. Background and management factors up to the development of CLD, with attention to mode of ventilation (tube, or face mask/nasal prongs) were investigated. Infants in the CLD group had significantly lower birth weights (BW) (p less than .001) and gestational ages (p less than .01) than those in the non-CLD group. There was no difference in the incidence of intrathoracic airleak or symptomatic patent ductus arteriosus. Of the CLD group, 74% were intubated compared with 35% in the non-CLD group (p less than .002). There was no difference between the groups in the morbidity score of initial pulmonary disease or in the duration of ventilation with various pressures and oxygen concentrations. Multiple logistic regression analysis revealed that intubated infants were 4.8 times more likely to develop CLD than nonintubated infants, and infants with low BW had a 3.2-fold greater risk of developing the disease. |
| Databáze: | OpenAIRE |
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