Maternal First Trimester TSH Concentrations: Do They Affect Perinatal and Endocrine Outcomes?
| Autor: | Victor Novack, Anat Tsur, Tali Shafat, Merav Fraenkel, J. Awesat, Y. Lichtenstein, Offer Erez |
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| Rok vydání: | 2016 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Thyrotropin 030209 endocrinology & metabolism Endocrine System Gestational Age Biochemistry Chorionic Gonadotropin 03 medical and health sciences 0302 clinical medicine Endocrinology Pregnancy Risk Factors Internal medicine medicine Endocrine system Humans 030219 obstetrics & reproductive medicine business.industry Obstetrics Thyroid disease Biochemistry (medical) Pregnancy Outcome Retrospective cohort study General Medicine Odds ratio medicine.disease First trimester Pregnancy Trimester First Thyrotoxicosis Quartile Multivariate Analysis Female Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 48(7) |
| ISSN: | 1439-4286 |
| Popis: | We aimed to examine the distribution of 1(st) trimester TSH and evaluate its association with perinatal outcomes and future development of maternal thyrotoxicosis. This retrospective cohort study included data of all women without prior thyroid disease who delivered a singleton at our medical center from 1/2001 to 12/2011 and had a 1(st) trimester TSH4.0 mU/l. Women were divided according to 1(st) trimester TSH concentrations into quartiles and by predefined TSH values (mU/l): 1) TSH0.1; 2) TSH 0.11-0.2; 3) TSH 0.21-0.4; and 4) TSH 0.4-4. Obstetrical outcomes, hCG concentrations, and future thyroid status were collected from electronic medical records. A total of 13 841 women fulfilled the inclusion criteria. Mean maternal TSH concentration at 5 weeks of gestation was 2.09±0.83 mU/l and decreased to 1.29±0.87 mU/l in weeks 8-9 with an increase towards the end of the 1(st) trimester. Odds ratio for future thyrotoxicosis was 3.64 in the lowest compared to the highest TSH quartile and 10.03 in those with TSH0.1 compared to TSH 0.41-4 mU/l. Rates of female fetuses were higher in the low TSH quartiles and in the lower TSH groups, however baby gender was not associated with increased risk of future thyrotoxicosis. Low maternal 1(st) trimester TSH quartiles or concentrations were not associated with adverse pregnancy outcome. Only a minor fraction of pregnant women with a low first tirmester TSH subsequently developed future thyrotoxicosis. |
| Databáze: | OpenAIRE |
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