Study of skin vasomotion in type 1 diabetic patients and of its possible relationship with clinical and laboratory variables
| Autor: | Margherita Pesce, Marco Rossi, Ottavio Giampietro, Fabio Galetta, Cristina Consani, Gino Santoro, Elena Matteucci |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Physiology Ischemia Vasomotion Microcirculation Forearm Physiology (medical) Internal medicine Linear regression Laser-Doppler Flowmetry medicine Pi Humans Skin Clinical Laboratory Techniques business.industry Heart rate variation Hematology Middle Aged medicine.disease Surgery Diabetes Mellitus Type 1 medicine.anatomical_structure Regional Blood Flow Cardiology Female Endothelium Vascular Cardiology and Cardiovascular Medicine business Perfusion |
| Zdroj: | Clinical Hemorheology and Microcirculation. 53:357-367 |
| ISSN: | 1386-0291 |
| Popis: | Vascular oscillation (vasomotion) occurs in the microcirculation and is thought to be a significant contributor to tissue perfusion. Our aim was to assess skin vasomotion (SV) of type 1 diabetic patients (T1D-pts) and its relationship with clinical or laboratory variables of the studied T1D-pts. Forearm endothelial-, sympathetic- and myogenic-dependent SV were assessed basally and after 3 min of forearm ischemia in 40 T1D-pts and 50 healthy controls, by spectral analysis of laser-Doppler (LD) signal at the frequency ranges of 0.009-0.02 Hz, 0.021-0.06 Hz and 0.061-0.2 Hz, respectively. Post-ischemic per cent increase (PI%-increase) in power spectral density (PSD) of skin endothelial- and sympathetic-dependent VS was significantly reduced in T1D-pts compared to controls (p < 0.0005, p < 0.0001, respectively). Linear regression analysis showed a significant positive relationship between PI%-increase of endothelial-dependent SV and heart rate variation during laying-standing test (R = 0.65, p = 0.00001), and a negative relationship between PI%-increase in PSD of skin LD signal 0.009-1.6 Hz spectrum and glycated haemoglobin serum levels (R = 0.44, p = 0.0036) in T1D-pts. These results are consistent with reduced skin endothelial- and sympathetic-dependent stimulated SV and with relationships between some clinical or laboratory variables and SV parameters in the T1D-pts studied. |
| Databáze: | OpenAIRE |
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