The effects of antipsychotics on weight gain, weight-related hormones and homocysteine in children and adolescents: a 1-year follow-up study

Autor: Pamela Rodríguez-Latorre, Inmaculada Baeza, Laura Vigo, Josefina Castro-Fornieles, Jessica Merchán-Naranjo, Rosa Calvo-Escalona, Celso Arango, Elena de la Serna
Rok vydání: 2015
Předmět:
Leptin
Male
Time Factors
medicine.medical_treatment
Overweight
Weight Gain
Benzodiazepines
0302 clinical medicine
Developmental and Educational Psychology
Insulin
Prospective Studies
Child
Homocysteine
education.field_of_study
General Medicine
Risperidone
Ghrelin
Psychiatry and Mental health
Treatment Outcome
Olanzapine
Child
Preschool
Female
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
Antipsychotic Agents
medicine.medical_specialty
Adolescent
Population
03 medical and health sciences
Insulin resistance
Internal medicine
medicine
Humans
Obesity
education
Adiponectin
business.industry
Body Weight
nutritional and metabolic diseases
medicine.disease
030227 psychiatry
Endocrinology
Pediatrics
Perinatology and Child Health
business
Weight gain
Body mass index
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: European childadolescent psychiatry. 26(1)
ISSN: 1435-165X
Popis: To analyze weight gain, metabolic hormones, and homocysteine (Hcys) levels in children and adolescents on antipsychotics (AP) during a year-long follow-up. 117 patients, AP-naive or quasi-naive (less than 30 days on AP), were included. Weight, body mass index (BMI), BMI z-score (z-BMI), and levels of leptin, insulin, insulin resistance (HOMA-IR), adiponectin, ghrelin, thyroid stimulating hormone (TSH), free thyroxine (FT4), and Hcys were measured at baseline, and at 3, 6, and 12 months, while patients remained on the same AP. Patients (mean age: 14.4 ± 3 years; 64.1 % male) were on risperidone (N = 84), olanzapine (N = 20) or quetiapine (N = 13) from baseline up to 1-year follow-up and significantly increased weight (5.8 ± 4.3 kg at 3-month, 8.1 ± 6.1 kg at 6-month, and 11.6 ± 7.0 kg at 1 year), BMI, and z-BMI. Leptin levels significantly increased from baseline to 3 and 6 months, as did TSH levels from baseline to 3 months, while FT4 levels decreased from baseline to 3 and 6 months. Patients with BMI >85th percentile at baseline (N = 16) significantly increased weight, BMI, and z-BMI, more than patients with normal BMI over time. Higher baseline levels of insulin, HOMA-IR, and leptin were associated with increased weight/BMI during follow-up, while higher baseline levels of FT4, adiponectin, and ghrelin were associated with lower weight/BMI during follow-up. All AP were associated with increased weight and BMI/z-BMI in all of the assessments; however, at 1-year assessment, this increase was significantly higher for patients on quetiapine. Both higher baseline levels of insulin, HOMA-IR, and leptin, as well as being overweight/obese at baseline were associated with increased weight/BMI during 1-year follow-up in children and adolescents on AP. Awareness of weight-related parameters in this population may help inform decisions regarding AP prescriptions.
Databáze: OpenAIRE
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