Adaptation and conservation insights from the koala genome
| Autor: | Danielle Madden, Camilla M. Whittington, Rachel J. O’Neill, Simon Y. W. Ho, Zhiliang Chen, Marilyn B. Renfree, Val Attenbrow, Andrew King, Graham J Etherington, Siobhan Dennison, Parice A. Brandies, David E. Alquezar-Planas, Emma Peel, Amber Gillett, Yuanyuan Cheng, Jennifer A. Marshall Graves, Thomas N. Heider, Greta J. Frankham, Donald J. Colgan, Elizabeth A. Jones, Katherine Belov, Carolyn J. Hogg, Janine E. Deakin, Federica Di Palma, Charles Robin, Catherine E. Grueber, Zachary Duda, Denis O’Meally, Alex D. Greenwood, Jason G. Bragg, Takashi Hayakawa, Clare E. Holleley, Amanda Yoon Yee Chong, Ryan Salinas, Matthew Hobbs, Belinda Wright, Will Nash, Arthur Georges, Kyle M. Ewart, Mark D. B. Eldridge, Adam Polkinghorne, Rebecca N. Johnson, Paul D. Waters, Peter Timms, Shafagh A. Waters, Merran Govendir, Katrina M. Morris, Tonia Russell, Kyriakos Tsangaras, Wilfried Haerty, Hardip R. Patel, Linda E. Neaves, Kristofer M. Helgen, Marc R. Wilkins |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Population genetics Population Genome Translocation Genetic 03 medical and health sciences Cytochrome P-450 Enzyme System Phascolarctos cinereus biology.animal Genetics Immunogenetics Animals Phascolarctidae education Marsupial Uncategorized education.field_of_study biology Australia Molecular Sequence Annotation 500 Naturwissenschaften und Mathematik::590 Tiere (Zoologie)::590 Tiere (Zoologie) Genomics Chlamydia Infections 15. Life on land biology.organism_classification Adaptation Physiological 030104 developmental biology Evolutionary biology FOS: Biological sciences Female Adaptation Zoology Reference genome |
| Zdroj: | Johnson, R N, O'Meally, D, Chen, Z, Etherington, G J, Ho, S Y W, Nash, W J, Grueber, C E, Cheng, Y, Whittington, C M, Dennison, S, Peel, E, Haerty, W, O'Neill, R J, Colgan, D, Russell, T L, Alquezar-Planas, D E, Attenbrow, V, Bragg, J G, Brandies, P A, Chong, A Y-Y, Deakin, J E, Di Palma, F, Duda, Z, Eldridge, M D B, Ewart, K M, Hogg, C J, Frankham, G J, Georges, A, Gillett, A K, Govendir, M, Greenwood, A D, Hayakawa, T, Helgen, K M, Hobbs, M, Holleley, C E, Heider, T N, Jones, E A, King, A, Madden, D, Graves, J A M, Morris, K M, Neaves, L E, Patel, H R, Polkinghorne, A, Renfree, M B, Robin, C, Salinas, R, Tsangaras, K, Waters, P D & Waters, S A 2018, ' Adaptation and conservation insights from the koala genome ', Nature Genetics, vol. 50, no. 8, pp. 1102-1111 . https://doi.org/10.1038/s41588-018-0153-5 Nature Genetics Nature genetics, 50:1102–1111 |
| Popis: | The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, including centromeres. We reveal that the koala’s ability to detoxify eucalypt foliage may be due to expansions within a cytochrome P450 gene family, and its ability to smell, taste and moderate ingestion of plant secondary metabolites may be due to expansions in the vomeronasal and taste receptors. We characterized novel lactation proteins that protect young in the pouch and annotated immune genes important for response to chlamydial disease. Historical demography showed a substantial population crash coincident with the decline of Australian megafauna, while contemporary populations had biogeographic boundaries and increased inbreeding in populations affected by historic translocations. We identified genetically diverse populations that require habitat corridors and instituting of translocation programs to aid the koala’s survival in the wild. コアラの全ゲノム配列の解読に成功 --コアラはなぜ猛毒のユーカリを食べるのか？--. 京都大学プレスリリース. 2018-07-04. |
| Databáze: | OpenAIRE |
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