Effect of Methanolic Extract of Scrophularia subuphylla on Ischemia and Reperfusion-Induced Myocardial Injury
| Autor: | Parina Asgharian, Negisa Seyed Toutounchi, Abbas Delazar, Alireza Garjani, Haleh Vaez, Maryam Rameshrad, Elhameh Nikkhah |
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| Rok vydání: | 2018 |
| Předmět: |
Scrophularia subuphylla
Flavonoid Ischemia lcsh:RS1-441 Pharmaceutical Science Pharmacology Infarct size 030226 pharmacology & pharmacy lcsh:Pharmacy and materia medica Coronary artery disease 03 medical and health sciences 0302 clinical medicine Therapeutic index Heart rate Medicine Scrophularia General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification biology business.industry Isolated heart Glycoside biology.organism_classification medicine.disease chemistry 030220 oncology & carcinogenesis Reperfusion business Arrhythmia |
| Zdroj: | Pharmaceutical Sciences, Vol 24, Iss 1, Pp 8-14 (2018) |
| ISSN: | 2383-2886 1735-403X |
| DOI: | 10.15171/ps.2018.03 |
| Popis: | Background: Coronary artery disease is a leading cause of death worldwide. The present study has been designed to investigate efficacy of methanolic extract of Scrophularia subuphylla (S. subuphylla) on ischemia and reperfusion-induced myocardial injury in isolated rat heart. Methods: The isolated male Wistar rat hearts (n= 5) were perfused by Krebs-Henseleit solution enriched with the extract (0, 1, 5, and 10 μg/ml), using the langendorff method. After 15 minutes stabilization, the hearts were subjected to 30 minutes regional ischemia and then 120 minutes reperfusion. Results: Administration of the extract did not improve any of cardiac markers of flow rate, heart rate and developed pressure. Number, percentage and duration of arrhythmias were not affected by any concentrations of the extract. However, the concentration of 1 and 5 µg/ml increased the VT duration compared to control group (P |
| Databáze: | OpenAIRE |
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