Perfecting DNA double-strand break repair on transcribed chromatin
| Autor: | Xin Yi Tan, Michael S.Y. Huen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
DNA Repair
Transcription Genetic DNA damage DNA repair Biology Biochemistry Genomic Instability 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Higher Order Chromatin Structure Transcription (biology) Transcriptional regulation Homeostasis Humans DNA Breaks Double-Stranded Molecular Biology 030304 developmental biology 0303 health sciences Chromatin Double Strand Break Repair Cell biology chemistry 030220 oncology & carcinogenesis DNA |
| Zdroj: | Essays in Biochemistry. 64:705-719 |
| ISSN: | 1744-1358 0071-1365 |
| Popis: | Timely repair of DNA double-strand break (DSB) entails coordination with the local higher order chromatin structure and its transaction activities, including transcription. Recent studies are uncovering how DSBs trigger transient suppression of nearby transcription to permit faithful DNA repair, failing of which leads to elevated chromosomal aberrations and cell hypersensitivity to DNA damage. Here, we summarize the molecular bases for transcriptional control during DSB metabolism, and discuss how the exquisite coordination between the two DNA-templated processes may underlie maintenance of genome stability and cell homeostasis. |
| Databáze: | OpenAIRE |
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