The role of Transfer RNA-Derived Small RNAs (tsRNAs) in Digestive System Tumors
| Autor: | Qian Xu, Ben-Gang Wang, Xin-Ping Zhong, Li-rong Yan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Small RNA RNA-binding protein Review Biology medicine.disease_cause 03 medical and health sciences tsRNAs 0302 clinical medicine tRFs Transcription (biology) medicine cancer Cell growth digestive system tumors tRNAs Cell biology 030104 developmental biology Oncology 030220 oncology & carcinogenesis Transfer RNA RNA splicing biology.protein tiRNAs Carcinogenesis Dicer |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.46055 |
| Popis: | Transfer RNA-derived small RNA(tsRNA) is a type of non-coding tRNA undergoing cleavage by specific nucleases such as Dicer. TsRNAs comprise of tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs). Based on the splicing site within the tRNA, tRFs can be classified into tRF-1, tRF-2, tRF-3, tRF-5, and i-tRF. TiRNAs can be classified into 5'-tiRNA and 3'-tiRNA. Both tRFs and tiRNAs have important roles in carcinogenesis, especially cancer of digestive system. TRFs and tiRNAs can promote cell proliferation and cell cycle progression by regulating the expression of oncogenes, combining with RNA binding proteins such as Y-box binding protein 1 (YBX1) to prevent transcription. Despite many reviews on the basic biological function of tRFs and tiRNAs, few have described their correlation with tumors especially gastrointestinal tumor. This review focused on the relationship of tRFs and tiRNAs with the biological behavior, clinicopathological characteristics, diagnosis, treatment and prognosis of digestive system tumors, and would provide novel insights for the early detection and treatment of digestive system tumors. |
| Databáze: | OpenAIRE |
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